Cited 90 times in
¹H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure
DC Field | Value | Language |
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dc.contributor.author | 강석민 | - |
dc.contributor.author | 오재원 | - |
dc.contributor.author | 정지형 | - |
dc.date.accessioned | 2014-12-20T16:23:18Z | - |
dc.date.available | 2014-12-20T16:23:18Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0009-9120 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92621 | - |
dc.description.abstract | OBJECTIVES: We sought to identify metabolic pathways characterizing human heart failure (HF) using ¹NMR based urinary metabolomic analysis in conjunction with multivariate statistics. DESIGN AND METHODS: Patients with systolic HF of ischemic origin (n=15) and healthy controls (n=20) participated in this study. Patients with type 2 diabetes mellitus were excluded. RESULTS: The results showed that the urine of the HF patients had higher levels of metabolites for acetate (p<0.05) and acetone (p<0.01) compared to the healthy controls. In addition, there was a perturbation in methylmalonate metabolism as shown by increased urinary levels of methylmalonic acid (p<0.001) in the HF patients. HF patients also had increased urinary levels of cytosine (p<0.01) and phenylacetylglycine (p<0.01) and decreased 1-methylnicotinamide (p<0.05) compared to healthy controls. CONCLUSIONS: TCA cycle metabolites and fatty acid metabolism were modified in the HF patients, indicating altered energy metabolism. Moreover, perturbations of metabolism in nucleotide and methylmalonate were observed. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 293~299 | - |
dc.relation.isPartOf | CLINICAL BIOCHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acetic Acid/urine | - |
dc.subject.MESH | Acetone/urine | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cytosine/urine | - |
dc.subject.MESH | Energy Metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glycine/analogs&derivatives | - |
dc.subject.MESH | Glycine/urine | - |
dc.subject.MESH | Heart Failure, Systolic/physiopathology | - |
dc.subject.MESH | Heart Failure, Systolic/urine* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metabolome | - |
dc.subject.MESH | Metabolomics | - |
dc.subject.MESH | Methylmalonic Acid/urine | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Myocardial Ischemia/physiopathology | - |
dc.subject.MESH | Myocardial Ischemia/urine* | - |
dc.subject.MESH | Niacinamide/analogs&derivatives | - |
dc.subject.MESH | Niacinamide/urine | - |
dc.subject.MESH | Nuclear Magnetic Resonance, Biomolecular | - |
dc.subject.MESH | Protons | - |
dc.subject.MESH | Urinalysis/methods* | - |
dc.title | ¹H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Research Institute for Cerebral & Cardiovascular Diseases (심혈관제품유효성평가센터) | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Jong-Chul Park | - |
dc.contributor.googleauthor | Min-Jeong Shin | - |
dc.contributor.googleauthor | Hyeran Lee | - |
dc.contributor.googleauthor | Jaewon Oh | - |
dc.contributor.googleauthor | Do Hyun Ryu | - |
dc.contributor.googleauthor | Geum-Sook Hwang | - |
dc.contributor.googleauthor | Ji Hyung Chung | - |
dc.identifier.doi | 10.1016/j.clinbiochem.2010.11.010 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00037 | - |
dc.contributor.localId | A03739 | - |
dc.contributor.localId | A02395 | - |
dc.relation.journalcode | J00561 | - |
dc.identifier.eissn | 1873-2933 | - |
dc.identifier.pmid | 21167146 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0009912010005114 | - |
dc.subject.keyword | Heart failure | - |
dc.subject.keyword | Citric acid cycle | - |
dc.subject.keyword | Metabolism | - |
dc.subject.keyword | Methylmalonic acid | - |
dc.subject.keyword | Phenylacetylglycine | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.alternativeName | Oh, Jae Won | - |
dc.contributor.alternativeName | Chung, Ji Hyung | - |
dc.contributor.affiliatedAuthor | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | Chung, Ji Hyung | - |
dc.contributor.affiliatedAuthor | Oh, Jae Won | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 44 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 293 | - |
dc.citation.endPage | 299 | - |
dc.identifier.bibliographicCitation | CLINICAL BIOCHEMISTRY, Vol.44(4) : 293-299, 2011 | - |
dc.identifier.rimsid | 28660 | - |
dc.type.rims | ART | - |
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