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EGFR polymorphism as a predictor of clinical outcome in advanced lung cancer patients treated with EGFR-TKI

Authors
 Minkyu Jung  ;  Byoung Chul Cho  ;  Ji Hyun Lee  ;  Joo Hang Kim  ;  Sun Young Rha  ;  Dae Jun Kim  ;  Joon Chang  ;  Se Kyu Kim  ;  Young Ae Kang  ;  Hyung Soon Park  ;  Chul Ho Lee 
Citation
 Yonsei Medical Journal, Vol.53(6) : 1128-1135, 2012 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2012
Abstract
PURPOSE: Mutations in the epidermal growth factor receptor (EGFR) have been confirmed as predictors of the efficacy of treatment with EGFR-tyrosine kinase inhibitors (TKIs). We investigated whether polymorphisms of the EGFR gene were associated with clinical outcomes in non-small cell lung cancer (NSCLC) patients treated with EGFR-TKI. MATERIALS AND METHODs: A polymorphic dinucleotide repeat in intron 1 [CA simple sequence repeat in intron 1(CA-SSR1)] in intron 1 and single nucleotide polymorphisms (SNP-216) in the promoter region of the EGFR gene were evaluated in 71 NSCLC patients by restriction fragment length polymorphism and DNA sequencing. The relationship between genetic polymorphisms and clinical outcomes of treatment with EGFR-TKIs was evaluated. RESULTS: SNP-216G/T polymorphisms were associated with the efficacy of EGFR-TKI. The response rate for the SNP-216G/T tended to be higher than that for G/G (62.5% vs. 27.4%, p=0.057). The SNP-216G/T genotype was also associated with longer progression-free survival compared with the GG genotype (16.7 months vs. 5.1 months, p=0.005). However, the length of CA-SSR1 was not associated with the efficacy of EGFR-TKI. CONCLUSION: SNP-216G/T polymorphism was a potential predictor of clinical outcomes in NSCLC patients treated with EGFR-TKI.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92161
DOI
10.3349/ymj.2012.53.6.1128
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Research Center for Human Natural Defense System (생체방어연구센터)
Yonsei Authors
강영애(Kang, Young Ae) ; 김대준(Kim, Dae Joon) ; 김세규(Kim, Se Kyu) ; 김주항(Kim, Joo Hang) ; 라선영(Rha, Sun Young) ; 박형순(Park, Hyung Soon) ; 이지현(Lee, Ji Hyun) ; 이철호(Lee, Chul Ho) ; 장준(Chang, Joon) ; 정민규(Jung, Min Kyu) ; 조병철(Cho, Byoung Chul)
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