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EGFR polymorphism as a predictor of clinical outcome in advanced lung cancer patients treated with EGFR-TKI

DC FieldValueLanguage
dc.contributor.author정민규-
dc.contributor.author조병철-
dc.contributor.author강영애-
dc.contributor.author김대준-
dc.contributor.author김세규-
dc.contributor.author김주항-
dc.contributor.author라선영-
dc.contributor.author박형순-
dc.contributor.author이지현-
dc.contributor.author이철호-
dc.contributor.author장준-
dc.date.accessioned2014-12-19T17:50:34Z-
dc.date.available2014-12-19T17:50:34Z-
dc.date.issued2012-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92161-
dc.description.abstractPURPOSE: Mutations in the epidermal growth factor receptor (EGFR) have been confirmed as predictors of the efficacy of treatment with EGFR-tyrosine kinase inhibitors (TKIs). We investigated whether polymorphisms of the EGFR gene were associated with clinical outcomes in non-small cell lung cancer (NSCLC) patients treated with EGFR-TKI. MATERIALS AND METHODs: A polymorphic dinucleotide repeat in intron 1 [CA simple sequence repeat in intron 1(CA-SSR1)] in intron 1 and single nucleotide polymorphisms (SNP-216) in the promoter region of the EGFR gene were evaluated in 71 NSCLC patients by restriction fragment length polymorphism and DNA sequencing. The relationship between genetic polymorphisms and clinical outcomes of treatment with EGFR-TKIs was evaluated. RESULTS: SNP-216G/T polymorphisms were associated with the efficacy of EGFR-TKI. The response rate for the SNP-216G/T tended to be higher than that for G/G (62.5% vs. 27.4%, p=0.057). The SNP-216G/T genotype was also associated with longer progression-free survival compared with the GG genotype (16.7 months vs. 5.1 months, p=0.005). However, the length of CA-SSR1 was not associated with the efficacy of EGFR-TKI. CONCLUSION: SNP-216G/T polymorphism was a potential predictor of clinical outcomes in NSCLC patients treated with EGFR-TKI.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1128~1135-
dc.relation.isPartOfYonsei Medical Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEGFR polymorphism as a predictor of clinical outcome in advanced lung cancer patients treated with EGFR-TKI-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorMinkyu Jung-
dc.contributor.googleauthorByoung Chul Cho-
dc.contributor.googleauthorChul Ho Lee-
dc.contributor.googleauthorHyung Soon Park-
dc.contributor.googleauthorYoung Ae Kang-
dc.contributor.googleauthorSe Kyu Kim-
dc.contributor.googleauthorJoon Chang-
dc.contributor.googleauthorDae Jun Kim-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorJoo Hang Kim-
dc.contributor.googleauthorJi Hyun Lee-
dc.identifier.doi10.3349/ymj.2012.53.6.1128-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03606-
dc.contributor.localIdA03822-
dc.contributor.localIdA00057-
dc.contributor.localIdA00368-
dc.contributor.localIdA00602-
dc.contributor.localIdA00945-
dc.contributor.localIdA03254-
dc.contributor.localIdA03472-
dc.contributor.localIdA01754-
dc.contributor.localIdA01316-
dc.contributor.localIdA03217-
dc.relation.journalcodeJ02813-
dc.contributor.alternativeNameJung, Min Kyu-
dc.contributor.alternativeNameCho, Byoung Chul-
dc.contributor.alternativeNameKang, Young Ae-
dc.contributor.alternativeNameKim, Dae Joon-
dc.contributor.alternativeNameKim, Se Kyu-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNamePark, Hyung Soon-
dc.contributor.alternativeNameLee, Ji Hyun-
dc.contributor.alternativeNameLee, Chul Ho-
dc.contributor.alternativeNameChang, Joon-
dc.contributor.affiliatedAuthorJung, Min Kyu-
dc.contributor.affiliatedAuthorCho, Byoung Chul-
dc.contributor.affiliatedAuthorKang, Young Ae-
dc.contributor.affiliatedAuthorKim, Dae Joon-
dc.contributor.affiliatedAuthorKim, Se Kyu-
dc.contributor.affiliatedAuthorKim, Joo Hang-
dc.contributor.affiliatedAuthorLee, Chul Ho-
dc.contributor.affiliatedAuthorChang, Joon-
dc.contributor.affiliatedAuthorPark, Hyung Soon-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.contributor.affiliatedAuthorLee, Ji Hyun-
dc.citation.volume53-
dc.citation.number6-
dc.citation.startPage1128-
dc.citation.endPage1135-
dc.identifier.bibliographicCitationYonsei Medical Journal, Vol.53(6) : 1128-1135, 2012-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Research Center for Human Natural Defense System (생체방어연구센터)

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