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Targetable gold nanorods for epithelial cancer therapy guided by near-IR absorption imaging

Authors
 Jihye Choi  ;  Jaemoon Yang  ;  Doyeon Bang  ;  Joseph Park  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 SMALL, Vol.8(5) : 746-753, 2012 
Journal Title
 SMALL 
ISSN
 1613-6810 
Issue Date
2012
MeSH
Absorption ; Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Cell Line, Tumor ; Cetuximab ; Gold ; Humans ; Hyperthermia, Induced/methods* ; Infrared Rays ; Metal Nanoparticles/administration & dosage ; Metal Nanoparticles/chemistry* ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Microscopy, Fluorescence ; Nanotubes ; Phototherapy/methods* ; Polyethylene Glycols/chemistry
Keywords
Absorption ; Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Cell Line, Tumor ; Cetuximab ; Gold ; Humans ; Hyperthermia, Induced/methods* ; Infrared Rays ; Metal Nanoparticles/administration & dosage ; Metal Nanoparticles/chemistry* ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Microscopy, Fluorescence ; Nanotubes ; Phototherapy/methods* ; Polyethylene Glycols/chemistry
Abstract
Well-designed nanoparticle-mediated, image-guided cancer therapy has attracted interest for increasing the efficacy of cancer treatment. A new class of smart theragnostic nanoprobes employing cetuximab (CET)-conjugated polyethylene glycol (PEG)ylated gold nanorods (CET-PGNRs) is presented; these nanoprobes target epithelial cancer cells using near-infrared light. The cetyltrimethylammonium bromide bilayer on GNRs is replaced with heterobifunctional PEG (COOH-PEG-SH) to serve as a biocompatible stabilizer and to increase specificity. The carboxylated GNRs are further functionalized with CET using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDC-NHS) chemistry. To assess the potential of such GNRs, their optical properties, biocompatibility, colloidal stability, in vitro/in vivo binding affinities for cancer cells, absorption imaging, and photothermal therapy effects are investigated. CET-PGNRs exhibit excellent tumor targeting ability and strong potential for simultaneous absorption imaging and photothermal ablation of epithelial cancer cells.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/smll.201101789/abstract
DOI
22271594
Appears in Collections:
5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91855
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