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Targetable gold nanorods for epithelial cancer therapy guided by near-IR absorption imaging

Authors
 Jihye Choi  ;  Jaemoon Yang  ;  Seungjoo Haam  ;  Yong-Min Huh  ;  Jin-Suck Suh  ;  Joseph Park  ;  Doyeon Bang 
Citation
 Small, Vol.8(5) : 746-753, 2012 
Journal Title
 Small 
ISSN
 1613-6810 
Issue Date
2012
Abstract
Well-designed nanoparticle-mediated, image-guided cancer therapy has attracted interest for increasing the efficacy of cancer treatment. A new class of smart theragnostic nanoprobes employing cetuximab (CET)-conjugated polyethylene glycol (PEG)ylated gold nanorods (CET-PGNRs) is presented; these nanoprobes target epithelial cancer cells using near-infrared light. The cetyltrimethylammonium bromide bilayer on GNRs is replaced with heterobifunctional PEG (COOH-PEG-SH) to serve as a biocompatible stabilizer and to increase specificity. The carboxylated GNRs are further functionalized with CET using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDC-NHS) chemistry. To assess the potential of such GNRs, their optical properties, biocompatibility, colloidal stability, in vitro/in vivo binding affinities for cancer cells, absorption imaging, and photothermal therapy effects are investigated. CET-PGNRs exhibit excellent tumor targeting ability and strong potential for simultaneous absorption imaging and photothermal ablation of epithelial cancer cells.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91855
DOI
10.1002/smll.201101789
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
서진석(Suh, Jin Suck) ; 양재문(Yang, Jae Moon) ; 허용민(Huh, Yong Min)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1002/smll.201101789/abstract
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