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Targetable gold nanorods for epithelial cancer therapy guided by near-IR absorption imaging
DC Field | Value | Language |
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dc.contributor.author | 서진석 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2014-12-19T17:40:58Z | - |
dc.date.available | 2014-12-19T17:40:58Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91855 | - |
dc.description.abstract | Well-designed nanoparticle-mediated, image-guided cancer therapy has attracted interest for increasing the efficacy of cancer treatment. A new class of smart theragnostic nanoprobes employing cetuximab (CET)-conjugated polyethylene glycol (PEG)ylated gold nanorods (CET-PGNRs) is presented; these nanoprobes target epithelial cancer cells using near-infrared light. The cetyltrimethylammonium bromide bilayer on GNRs is replaced with heterobifunctional PEG (COOH-PEG-SH) to serve as a biocompatible stabilizer and to increase specificity. The carboxylated GNRs are further functionalized with CET using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDC-NHS) chemistry. To assess the potential of such GNRs, their optical properties, biocompatibility, colloidal stability, in vitro/in vivo binding affinities for cancer cells, absorption imaging, and photothermal therapy effects are investigated. CET-PGNRs exhibit excellent tumor targeting ability and strong potential for simultaneous absorption imaging and photothermal ablation of epithelial cancer cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 746~753 | - |
dc.relation.isPartOf | SMALL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Absorption | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antibodies, Monoclonal/administration & dosage | - |
dc.subject.MESH | Antibodies, Monoclonal/chemistry | - |
dc.subject.MESH | Antibodies, Monoclonal/therapeutic use | - |
dc.subject.MESH | Antibodies, Monoclonal, Humanized | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cetuximab | - |
dc.subject.MESH | Gold | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyperthermia, Induced/methods* | - |
dc.subject.MESH | Infrared Rays | - |
dc.subject.MESH | Metal Nanoparticles/administration & dosage | - |
dc.subject.MESH | Metal Nanoparticles/chemistry* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Microscopy, Fluorescence | - |
dc.subject.MESH | Nanotubes | - |
dc.subject.MESH | Phototherapy/methods* | - |
dc.subject.MESH | Polyethylene Glycols/chemistry | - |
dc.title | Targetable gold nanorods for epithelial cancer therapy guided by near-IR absorption imaging | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) | - |
dc.contributor.googleauthor | Jihye Choi | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Doyeon Bang | - |
dc.contributor.googleauthor | Joseph Park | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 22271594 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A04359 | - |
dc.contributor.localId | A02315 | - |
dc.relation.journalcode | J02664 | - |
dc.identifier.eissn | 1613-6829 | - |
dc.identifier.pmid | 22271594 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/smll.201101789/abstract | - |
dc.subject.keyword | Absorption | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Antibodies, Monoclonal/administration & dosage | - |
dc.subject.keyword | Antibodies, Monoclonal/chemistry | - |
dc.subject.keyword | Antibodies, Monoclonal/therapeutic use | - |
dc.subject.keyword | Antibodies, Monoclonal, Humanized | - |
dc.subject.keyword | Cell Line, Tumor | - |
dc.subject.keyword | Cetuximab | - |
dc.subject.keyword | Gold | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Hyperthermia, Induced/methods* | - |
dc.subject.keyword | Infrared Rays | - |
dc.subject.keyword | Metal Nanoparticles/administration & dosage | - |
dc.subject.keyword | Metal Nanoparticles/chemistry* | - |
dc.subject.keyword | Mice | - |
dc.subject.keyword | Mice, Inbred BALB C | - |
dc.subject.keyword | Mice, Nude | - |
dc.subject.keyword | Microscopy, Fluorescence | - |
dc.subject.keyword | Nanotubes | - |
dc.subject.keyword | Phototherapy/methods* | - |
dc.subject.keyword | Polyethylene Glycols/chemistry | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.citation.volume | 8 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 746 | - |
dc.citation.endPage | 753 | - |
dc.identifier.bibliographicCitation | SMALL, Vol.8(5) : 746-753, 2012 | - |
dc.identifier.rimsid | 29963 | - |
dc.type.rims | ART | - |
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