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Osteoinductive activity of biphasic calcium phosphate with different rhBMP-2 doses in rats

Authors
 Ji-Woong Jang  ;  Jeong-Ho Yun  ;  Kwang-Il Lee  ;  Ju-Woong Jang  ;  Ui-Won Jung  ;  Chang-Sung Kim  ;  Seong-Ho Choi  ;  Kyoo-Sung Cho 
Citation
 Oral Surgery Oral Medicine Oral Pathology Oral Radiology, Vol.113(4) : 480-487, 2012 
Journal Title
 Oral Surgery Oral Medicine Oral Pathology Oral Radiology 
ISSN
 1079-2104 
Issue Date
2012
Abstract
OBJECTIVE: The aim of the current study was to determine whether a hydroxyapatite (HA)/beta-tricalcium phosphate (β-TCP) ratio of 20/80 impregnated with recombinant human bone morphogenetic protein (rhBMP-2) enhances new bone formation and to evaluate the dose-dependent response of rhBMP-2. STUDY DESIGN: Critical-sized calvarial defects were made in rats, and biphasic calcium phosphate (BCP) with different rhBMP-2 doses was loaded into rat calvarial defects. The animals were allowed to heal for either 2 or 8 weeks. RESULTS: The percentages of new bone after 2 and 8 weeks of healing were significantly greater in the rhBMP-2-treated groups (at all doses) than in the control groups. The percentage of remaining BCP was significantly lower at 8 weeks than at 2 weeks in all groups that included BCP. CONCLUSIONS: rhBMP-2 administered using a BCP carrier significantly induces new bone formation. A dose-dependent response was not shown in the present study.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91614
DOI
10.1016/j.tripleo.2011.04.013
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실)
Yonsei Authors
김창성(Kim, Chang Sung) ; 정의원(Jung, Ui Won) ; 조규성(Cho, Kyoo Sung) ; 최성호(Choi, Seong Ho)
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Full Text
http://www.sciencedirect.com/science/article/pii/S1079210411002459
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