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Osteoinductive activity of biphasic calcium phosphate with different rhBMP-2 doses in rats

Authors
 Ji-Woong Jang  ;  Jeong-Ho Yun  ;  Kwang-Il Lee  ;  Ju-Woong Jang  ;  Ui-Won Jung  ;  Chang-Sung Kim  ;  Seong-Ho Choi  ;  Kyoo-Sung Cho 
Citation
 ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, Vol.113(4) : 480-487, 2012 
Journal Title
 ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 
ISSN
 2212-4403 
Issue Date
2012
MeSH
Animals ; Bone Morphogenetic Protein 2/administration & dosage ; Bone Morphogenetic Protein 2/pharmacology* ; Bone Substitutes/pharmacology* ; Drug Carriers* ; Hydroxyapatites/pharmacology* ; Osteogenesis/drug effects* ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins ; Skull/diagnostic imaging ; Skull/surgery ; X-Ray Microtomography
Keywords
Animals ; Bone Morphogenetic Protein 2/administration & dosage ; Bone Morphogenetic Protein 2/pharmacology* ; Bone Substitutes/pharmacology* ; Drug Carriers* ; Hydroxyapatites/pharmacology* ; Osteogenesis/drug effects* ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins ; Skull/diagnostic imaging ; Skull/surgery ; X-Ray Microtomography
Abstract
OBJECTIVE: The aim of the current study was to determine whether a hydroxyapatite (HA)/beta-tricalcium phosphate (β-TCP) ratio of 20/80 impregnated with recombinant human bone morphogenetic protein (rhBMP-2) enhances new bone formation and to evaluate the dose-dependent response of rhBMP-2. STUDY DESIGN: Critical-sized calvarial defects were made in rats, and biphasic calcium phosphate (BCP) with different rhBMP-2 doses was loaded into rat calvarial defects. The animals were allowed to heal for either 2 or 8 weeks. RESULTS: The percentages of new bone after 2 and 8 weeks of healing were significantly greater in the rhBMP-2-treated groups (at all doses) than in the control groups. The percentage of remaining BCP was significantly lower at 8 weeks than at 2 weeks in all groups that included BCP. CONCLUSIONS: rhBMP-2 administered using a BCP carrier significantly induces new bone formation. A dose-dependent response was not shown in the present study.
Full Text
http://www.sciencedirect.com/science/article/pii/S1079210411002459
DOI
22676929
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91614
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