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Osteoinductive activity of biphasic calcium phosphate with different rhBMP-2 doses in rats

DC FieldValueLanguage
dc.contributor.author김창성-
dc.contributor.author정의원-
dc.contributor.author조규성-
dc.contributor.author최성호-
dc.date.accessioned2014-12-19T17:32:53Z-
dc.date.available2014-12-19T17:32:53Z-
dc.date.issued2012-
dc.identifier.issn1079-2104-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91614-
dc.description.abstractOBJECTIVE: The aim of the current study was to determine whether a hydroxyapatite (HA)/beta-tricalcium phosphate (β-TCP) ratio of 20/80 impregnated with recombinant human bone morphogenetic protein (rhBMP-2) enhances new bone formation and to evaluate the dose-dependent response of rhBMP-2. STUDY DESIGN: Critical-sized calvarial defects were made in rats, and biphasic calcium phosphate (BCP) with different rhBMP-2 doses was loaded into rat calvarial defects. The animals were allowed to heal for either 2 or 8 weeks. RESULTS: The percentages of new bone after 2 and 8 weeks of healing were significantly greater in the rhBMP-2-treated groups (at all doses) than in the control groups. The percentage of remaining BCP was significantly lower at 8 weeks than at 2 weeks in all groups that included BCP. CONCLUSIONS: rhBMP-2 administered using a BCP carrier significantly induces new bone formation. A dose-dependent response was not shown in the present study.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfOral Surgery Oral Medicine Oral Pathology Oral Radiology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleOsteoinductive activity of biphasic calcium phosphate with different rhBMP-2 doses in rats-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Periodontology (치주과학)-
dc.contributor.googleauthorJi-Woong Jang-
dc.contributor.googleauthorJeong-Ho Yun-
dc.contributor.googleauthorKwang-Il Lee-
dc.contributor.googleauthorJu-Woong Jang-
dc.contributor.googleauthorUi-Won Jung-
dc.contributor.googleauthorChang-Sung Kim-
dc.contributor.googleauthorSeong-Ho Choi-
dc.contributor.googleauthorKyoo-Sung Cho-
dc.identifier.doi10.1016/j.tripleo.2011.04.013-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01041-
dc.contributor.localIdA03692-
dc.contributor.localIdA03810-
dc.contributor.localIdA04081-
dc.relation.journalcodeJ02442-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1079210411002459-
dc.contributor.alternativeNameKim, Chang Sung-
dc.contributor.alternativeNameJung, Ui Won-
dc.contributor.alternativeNameCho, Kyoo Sung-
dc.contributor.alternativeNameChoi, Seong Ho-
dc.contributor.affiliatedAuthorKim, Chang Sung-
dc.contributor.affiliatedAuthorJung, Ui Won-
dc.contributor.affiliatedAuthorCho, Kyoo Sung-
dc.contributor.affiliatedAuthorChoi, Seong Ho-
dc.citation.volume113-
dc.citation.number4-
dc.citation.startPage480-
dc.citation.endPage487-
dc.identifier.bibliographicCitationOral Surgery Oral Medicine Oral Pathology Oral Radiology, Vol.113(4) : 480-487, 2012-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

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