Cited 68 times in
Osteoinductive activity of biphasic calcium phosphate with different rhBMP-2 doses in rats
DC Field | Value | Language |
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dc.contributor.author | 김창성 | - |
dc.contributor.author | 정의원 | - |
dc.contributor.author | 조규성 | - |
dc.contributor.author | 최성호 | - |
dc.date.accessioned | 2014-12-19T17:32:53Z | - |
dc.date.available | 2014-12-19T17:32:53Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 2212-4403 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91614 | - |
dc.description.abstract | OBJECTIVE: The aim of the current study was to determine whether a hydroxyapatite (HA)/beta-tricalcium phosphate (β-TCP) ratio of 20/80 impregnated with recombinant human bone morphogenetic protein (rhBMP-2) enhances new bone formation and to evaluate the dose-dependent response of rhBMP-2. STUDY DESIGN: Critical-sized calvarial defects were made in rats, and biphasic calcium phosphate (BCP) with different rhBMP-2 doses was loaded into rat calvarial defects. The animals were allowed to heal for either 2 or 8 weeks. RESULTS: The percentages of new bone after 2 and 8 weeks of healing were significantly greater in the rhBMP-2-treated groups (at all doses) than in the control groups. The percentage of remaining BCP was significantly lower at 8 weeks than at 2 weeks in all groups that included BCP. CONCLUSIONS: rhBMP-2 administered using a BCP carrier significantly induces new bone formation. A dose-dependent response was not shown in the present study. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Morphogenetic Protein 2/administration & dosage | - |
dc.subject.MESH | Bone Morphogenetic Protein 2/pharmacology* | - |
dc.subject.MESH | Bone Substitutes/pharmacology* | - |
dc.subject.MESH | Drug Carriers* | - |
dc.subject.MESH | Hydroxyapatites/pharmacology* | - |
dc.subject.MESH | Osteogenesis/drug effects* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Recombinant Proteins | - |
dc.subject.MESH | Skull/diagnostic imaging | - |
dc.subject.MESH | Skull/surgery | - |
dc.subject.MESH | X-Ray Microtomography | - |
dc.title | Osteoinductive activity of biphasic calcium phosphate with different rhBMP-2 doses in rats | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontology (치주과학) | - |
dc.contributor.googleauthor | Ji-Woong Jang | - |
dc.contributor.googleauthor | Jeong-Ho Yun | - |
dc.contributor.googleauthor | Kwang-Il Lee | - |
dc.contributor.googleauthor | Ju-Woong Jang | - |
dc.contributor.googleauthor | Ui-Won Jung | - |
dc.contributor.googleauthor | Chang-Sung Kim | - |
dc.contributor.googleauthor | Seong-Ho Choi | - |
dc.contributor.googleauthor | Kyoo-Sung Cho | - |
dc.identifier.doi | 10.1016/j.tripleo.2011.04.013 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01041 | - |
dc.contributor.localId | A03692 | - |
dc.contributor.localId | A03810 | - |
dc.contributor.localId | A04081 | - |
dc.relation.journalcode | J02442 | - |
dc.identifier.pmid | 22676929 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1079210411002459 | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Bone Morphogenetic Protein 2/administration & dosage | - |
dc.subject.keyword | Bone Morphogenetic Protein 2/pharmacology* | - |
dc.subject.keyword | Bone Substitutes/pharmacology* | - |
dc.subject.keyword | Drug Carriers* | - |
dc.subject.keyword | Hydroxyapatites/pharmacology* | - |
dc.subject.keyword | Osteogenesis/drug effects* | - |
dc.subject.keyword | Rats | - |
dc.subject.keyword | Rats, Sprague-Dawley | - |
dc.subject.keyword | Recombinant Proteins | - |
dc.subject.keyword | Skull/diagnostic imaging | - |
dc.subject.keyword | Skull/surgery | - |
dc.subject.keyword | X-Ray Microtomography | - |
dc.contributor.alternativeName | Kim, Chang Sung | - |
dc.contributor.alternativeName | Jung, Ui Won | - |
dc.contributor.alternativeName | Cho, Kyoo Sung | - |
dc.contributor.alternativeName | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Kim, Chang Sung | - |
dc.contributor.affiliatedAuthor | Jung, Ui Won | - |
dc.contributor.affiliatedAuthor | Cho, Kyoo Sung | - |
dc.contributor.affiliatedAuthor | Choi, Seong Ho | - |
dc.citation.volume | 113 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 480 | - |
dc.citation.endPage | 487 | - |
dc.identifier.bibliographicCitation | ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, Vol.113(4) : 480-487, 2012 | - |
dc.identifier.rimsid | 29341 | - |
dc.type.rims | ART | - |
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