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Vitamin A deficiency induces fluid hyposecretion from the airway submucosal glands of mice

Authors
 Sang Cheol Kim  ;  Hyun Jae Lee  ;  Jung-Hee Joo  ;  Joo-Heon Yoon  ;  Jae Young Choi 
Citation
 JOURNAL OF NUTRITION, Vol.142(4) : 739-743, 2012 
Journal Title
 JOURNAL OF NUTRITION 
ISSN
 0022-3166 
Issue Date
2012
MeSH
Animals ; Bodily Secretions/enzymology ; Bodily Secretions/immunology ; Bodily Secretions/secretion ; Cell Count ; Chemokine CXCL2/genetics ; Chemokine CXCL2/metabolism ; Disease Resistance ; Down-Regulation* ; Male ; Mice ; Mice, Inbred C57BL ; Mucus/enzymology ; Mucus/immunology ; Mucus/secretion* ; Muramidase/secretion ; Phosphorylation ; Protein Processing, Post-Translational ; Pseudomonas Infections/immunology ; Pseudomonas Infections/pathology ; Pseudomonas aeruginosa/growth & development ; Pseudomonas aeruginosa/immunology ; RNA, Messenger/metabolism ; Receptor, Epidermal Growth Factor/metabolism ; Respiratory Mucosa/immunology ; Respiratory Mucosa/pathology ; Respiratory Mucosa/physiopathology ; Respiratory Mucosa/secretion* ; Respiratory Tract Infections/immunology ; Respiratory Tract Infections/pathology ; Severity of Illness Index ; Up-Regulation ; Vitamin A Deficiency/immunology ; Vitamin A Deficiency/metabolism ; Vitamin A Deficiency/pathology ; Vitamin A Deficiency/physiopathology*
Keywords
Animals ; Bodily Secretions/enzymology ; Bodily Secretions/immunology ; Bodily Secretions/secretion ; Cell Count ; Chemokine CXCL2/genetics ; Chemokine CXCL2/metabolism ; Disease Resistance ; Down-Regulation* ; Male ; Mice ; Mice, Inbred C57BL ; Mucus/enzymology ; Mucus/immunology ; Mucus/secretion* ; Muramidase/secretion ; Phosphorylation ; Protein Processing, Post-Translational ; Pseudomonas Infections/immunology ; Pseudomonas Infections/pathology ; Pseudomonas aeruginosa/growth & development ; Pseudomonas aeruginosa/immunology ; RNA, Messenger/metabolism ; Receptor, Epidermal Growth Factor/metabolism ; Respiratory Mucosa/immunology ; Respiratory Mucosa/pathology ; Respiratory Mucosa/physiopathology ; Respiratory Mucosa/secretion* ; Respiratory Tract Infections/immunology ; Respiratory Tract Infections/pathology ; Severity of Illness Index ; Up-Regulation ; Vitamin A Deficiency/immunology ; Vitamin A Deficiency/metabolism ; Vitamin A Deficiency/pathology ; Vitamin A Deficiency/physiopathology*
Abstract
Vitamin A deficiency (VAD) alters the phenotype of airway epithelium and attenuates the epithelial defense system, and many studies have reported the association of VAD with respiratory disease. In this study, we investigated changes in submucosal glands (SMG) in a mouse model of VAD. C57BL/6 mice were fed a vitamin A-devoid diet and the others were fed a control diet (1.2 mg retinol/kg). The areas of serous and mucous cells of SMG were measured in 4-, 8-, and 20-wk-old male mice. The volume and lysozyme concentration of glandular secretions were also measured. The 2 groups did not differ in body weight or general morbidity at 3-10 wk of age, although serum retinol concentrations were greater in the control mice than in the VAD mice after 4 wk. Upon histological evaluation, we found that the areal ratio of serous cells:total SMG cells was significantly lower after 8 wk in the VAD mice compared with the control mice, although the total area of SMG did not differ between groups throughout the 20-wk experiment. The number of secretory bubbles did not differ between the groups, but total secretion volume was reduced by 35% in 8-wk-old VAD mice compared with controls. Furthermore, the concentration of lysozyme in secretions from 8-wk-old VAD mice was also less than in controls, compounding the effect of diminished secretion volume. In this study, we found serous cell hypotrophy/hypoplasia and dysfunction in VAD mice, which may contribute to the susceptibility to airway infection linked to VAD.
Files in This Item:
T201201749.pdf Download
DOI
22399523
Appears in Collections:
5. Research Institutes (연구소) > Research Center for Human Natural Defense System (생체방어연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Sang Cheol(김상철)
Yoon, Joo Heon(윤주헌)
Lee, Hyun Jae(이현재)
Joo, Jung Hee(주정희)
Choi, Jae Young(최재영) ORCID logo https://orcid.org/0000-0001-9493-3458
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91016
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