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Subcortical white matter hyperintensities within the cholinergic pathways of Parkinson's disease patients according to cognitive status

Authors
 Jaeseung Shin  ;  Sungeun Choi  ;  Ji E Lee  ;  Hye Sun Lee  ;  Young H Sohn  ;  Phil Hyu Lee 
Citation
 JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol.83(1) : 315-321, 2012 
Journal Title
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
ISSN
 0022-3050 
Issue Date
2012
MeSH
Aged ; Cholinergic Neurons/pathology* ; Cholinergic Neurons/physiology ; Cognition Disorders/etiology ; Cognition Disorders/pathology* ; Cognition Disorders/physiopathology ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/pathology ; Cognitive Dysfunction/physiopathology ; Dementia/etiology ; Dementia/pathology ; Dementia/physiopathology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Neuroimaging ; Neuropsychological Tests ; Parkinson Disease/complications ; Parkinson Disease/pathology* ; Parkinson Disease/physiopathology ; Prospective Studies
Keywords
Aged ; Cholinergic Neurons/pathology* ; Cholinergic Neurons/physiology ; Cognition Disorders/etiology ; Cognition Disorders/pathology* ; Cognition Disorders/physiopathology ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/pathology ; Cognitive Dysfunction/physiopathology ; Dementia/etiology ; Dementia/pathology ; Dementia/physiopathology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Neuroimaging ; Neuropsychological Tests ; Parkinson Disease/complications ; Parkinson Disease/pathology* ; Parkinson Disease/physiopathology ; Prospective Studies
Abstract
BACKGROUND: White matter hyperintensities (WMH) in the cholinergic pathways show a stronger correlation with cognitive performance than general WMH in Alzheimer's disease. However, the role of WMH within the cholinergic pathways in cognitive dysfunction has not been investigated in Parkinson's disease (PD).

METHOD: The severity of WMH within the cholinergic pathways of PD subgroups with intact cognition (PD-IC, n=44), mild cognitive impairment (PD-MCI, n=87) and dementia (PDD, n=40) were compared using the Cholinergic Pathways Hyperintensities Scale (CHIPS), and the correlation between the CHIPS score and performance on individual tests of cognitive subdomains were analysed.

RESULTS: The mean CHIPS score was significantly higher in patients with PDD compared with those with PD-IC (p=0.03) or PD-MCI (p=0.015). The CHIPS score in patients with PD was negatively correlated with general cognition assessed using the Mini-Mental State Examination (r=-0.28, p<0.001) and positively with the Unified Parkinson's Disease Rating Scale motor score (r=0.24, p=0.002). The CHIPS score showed a significant correlation with cognitive performance on individual cognitive subdomains and had the highest independent correlations with contrasting programme (β=-0.33, p<0.001) and forward digit span (β=-0.17, p=0.04).

CONCLUSIONS: This study demonstrated that the burden of WMH within cholinergic pathways was significantly higher in patients with PDD relative to other groups, and that cholinergic WMH was significantly correlated with a decline in frontal executive function and attention.
Full Text
http://jnnp.bmj.com/content/83/3/315.long
DOI
10.1136/jnnp-2011-300872
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Shin, Jae Seung(신재승)
Lee, Ji Eun(이지은)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90992
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