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Subcortical white matter hyperintensities within the cholinergic pathways of Parkinson's disease patients according to cognitive status

DC Field Value Language
dc.contributor.author손영호-
dc.contributor.author신재승-
dc.contributor.author이지은-
dc.contributor.author이필휴-
dc.contributor.author이혜선-
dc.date.accessioned2014-12-19T17:12:55Z-
dc.date.available2014-12-19T17:12:55Z-
dc.date.issued2012-
dc.identifier.issn0022-3050-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90992-
dc.description.abstractBACKGROUND: White matter hyperintensities (WMH) in the cholinergic pathways show a stronger correlation with cognitive performance than general WMH in Alzheimer's disease. However, the role of WMH within the cholinergic pathways in cognitive dysfunction has not been investigated in Parkinson's disease (PD). METHOD: The severity of WMH within the cholinergic pathways of PD subgroups with intact cognition (PD-IC, n=44), mild cognitive impairment (PD-MCI, n=87) and dementia (PDD, n=40) were compared using the Cholinergic Pathways Hyperintensities Scale (CHIPS), and the correlation between the CHIPS score and performance on individual tests of cognitive subdomains were analysed. RESULTS: The mean CHIPS score was significantly higher in patients with PDD compared with those with PD-IC (p=0.03) or PD-MCI (p=0.015). The CHIPS score in patients with PD was negatively correlated with general cognition assessed using the Mini-Mental State Examination (r=-0.28, p<0.001) and positively with the Unified Parkinson's Disease Rating Scale motor score (r=0.24, p=0.002). The CHIPS score showed a significant correlation with cognitive performance on individual cognitive subdomains and had the highest independent correlations with contrasting programme (β=-0.33, p<0.001) and forward digit span (β=-0.17, p=0.04). CONCLUSIONS: This study demonstrated that the burden of WMH within cholinergic pathways was significantly higher in patients with PDD relative to other groups, and that cholinergic WMH was significantly correlated with a decline in frontal executive function and attention.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCholinergic Neurons/pathology*-
dc.subject.MESHCholinergic Neurons/physiology-
dc.subject.MESHCognition Disorders/etiology-
dc.subject.MESHCognition Disorders/pathology*-
dc.subject.MESHCognition Disorders/physiopathology-
dc.subject.MESHCognitive Dysfunction/etiology-
dc.subject.MESHCognitive Dysfunction/pathology-
dc.subject.MESHCognitive Dysfunction/physiopathology-
dc.subject.MESHDementia/etiology-
dc.subject.MESHDementia/pathology-
dc.subject.MESHDementia/physiopathology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHNeuroimaging-
dc.subject.MESHNeuropsychological Tests-
dc.subject.MESHParkinson Disease/complications-
dc.subject.MESHParkinson Disease/pathology*-
dc.subject.MESHParkinson Disease/physiopathology-
dc.subject.MESHProspective Studies-
dc.titleSubcortical white matter hyperintensities within the cholinergic pathways of Parkinson's disease patients according to cognitive status-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthorJaeseung Shin-
dc.contributor.googleauthorSungeun Choi-
dc.contributor.googleauthorJi E Lee-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorYoung H Sohn-
dc.contributor.googleauthorPhil Hyu Lee-
dc.identifier.doi10.1136/jnnp-2011-300872-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01982-
dc.contributor.localIdA02139-
dc.contributor.localIdA03270-
dc.contributor.localIdA03210-
dc.contributor.localIdA03312-
dc.relation.journalcodeJ01628-
dc.identifier.eissn1468-330X-
dc.identifier.pmid22228726-
dc.identifier.urlhttp://jnnp.bmj.com/content/83/3/315.long-
dc.subject.keywordAged-
dc.subject.keywordCholinergic Neurons/pathology*-
dc.subject.keywordCholinergic Neurons/physiology-
dc.subject.keywordCognition Disorders/etiology-
dc.subject.keywordCognition Disorders/pathology*-
dc.subject.keywordCognition Disorders/physiopathology-
dc.subject.keywordCognitive Dysfunction/etiology-
dc.subject.keywordCognitive Dysfunction/pathology-
dc.subject.keywordCognitive Dysfunction/physiopathology-
dc.subject.keywordDementia/etiology-
dc.subject.keywordDementia/pathology-
dc.subject.keywordDementia/physiopathology-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordMagnetic Resonance Imaging-
dc.subject.keywordMale-
dc.subject.keywordNeuroimaging-
dc.subject.keywordNeuropsychological Tests-
dc.subject.keywordParkinson Disease/complications-
dc.subject.keywordParkinson Disease/pathology*-
dc.subject.keywordParkinson Disease/physiopathology-
dc.subject.keywordProspective Studies-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameShin, Jae Seung-
dc.contributor.alternativeNameLee, Ji Eun-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.contributor.affiliatedAuthorShin, Jae Seung-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorLee, Ji Eun-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.citation.volume83-
dc.citation.number1-
dc.citation.startPage315-
dc.citation.endPage321-
dc.identifier.bibliographicCitationJOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol.83(1) : 315-321, 2012-
dc.identifier.rimsid33264-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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