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Gold nanorod-mediated photothermal modulation for localized ablation of cancer cells

Authors
 Yoochan Hong  ;  Eugene Lee  ;  Jihye Choi  ;  Seung Jae Oh  ;  Seungjoo Haam  ;  Yong-Min Huh  ;  Dae Sung Yoon  ;  Jin-Suck Suh  ;  Jaemoon Yang 
Citation
 JOURNAL OF NANOMATERIALS, Vol.2012 : 825060, 2012 
Journal Title
JOURNAL OF NANOMATERIALS
ISSN
 1687-4110 
Issue Date
2012
Abstract
We estimated the photothermal transduction efficiency of gold nanorod (GNR) solutions for different GNR concentrations and irradiation laser power. In particular, we verified that the degree of cell death area could be modulated by GNR concentration and irradiation laser power. The efficacy of GNR-produced photothermal ablation of cancer cells was evaluated by irradiating GNRs in the presence of MDA-MB-231 breast cancer cells with a near-infrared (NIR) laser at different laser power densities and irradiation times. GNR-induced photothermal ablation was applied successfully to cancer cells at various NIR laser power densities and irradiation times and was characterized with live-dead cell staining. Through these techniques, we established the system for not only verification of induced photothermal effect using NIR laser and thermocouple, but also identification of uptake efficiency for GNRs and cell viability using dark field and fluorescence imaging, respectively.
Files in This Item:
T201204105.pdf Download
DOI
10.1155/2012/825060
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Oh, Seung Jae(오승재)
Lee, Eu Gene(이유진)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90978
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