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Plasma phospholipid fatty acid composition and estimated desaturase activity in heart failure patients with metabolic syndrome

Authors
 Seungmin Lee  ;  Hyun Ju Do  ;  Seok-Min Kang  ;  Ji Hyung Chung  ;  Eunju Park  ;  Min-Jeong Shin 
Citation
 JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, Vol.51(2) : 150-155, 2012 
Journal Title
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
ISSN
 0912-0009 
Issue Date
2012
Keywords
desaturase ; dihomo-γ-linolenic acid ; fatty acid ; heart failure ; metabolic syndrome
Abstract
Metabolic syndrome is one of the major factors to increase the incidence of heart failure. In our study, we compared plasma fatty acid compositions among heart failure patients with and without Metabolic syndrome. Fatty acid (FA) composition of plasma phospholipids was analyzed and the activities of desaturase were estimated as the ratio of substrate and product fatty acids in 85 stable heart failure patients. Fatty acid and estimated desaturase activities were further examined for their associations with Metabolic syndrome components. Heart failure patients with Metabolic syndrome showed significant changes in fatty acid composition in comparison to those without Metabolic syndrome, which had a decreased proportion of lauric acid (C12:0) and an increased proportion of dihomo-γ-linolenic acid (C20:3n-6). Also, estimated desaturase activities (D5D and D6D) were closely related to Metabolic syndrome condition among heart failure patients. The content of dihomo-γ-linolenic acid showed positive correlations with BMI, waist circumference, and plasma triglyceride levels. D6D were positively associated with plasma triglyceride levels, whereas D5D showed a negative correlation with plasma triglyceride levels and waist circumferences. The content of dihomo-γ-linolenic acid as well as estimated D6D and D5D were altered in heart failure patients with Metabolic syndrome.
Files in This Item:
T201203756.pdf Download
DOI
22962535
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Chung, Ji Hyung(정지형)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90675
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