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Plasma phospholipid fatty acid composition and estimated desaturase activity in heart failure patients with metabolic syndrome

DC Field Value Language
dc.contributor.author강석민-
dc.contributor.author정지형-
dc.date.accessioned2014-12-19T17:02:46Z-
dc.date.available2014-12-19T17:02:46Z-
dc.date.issued2012-
dc.identifier.issn0912-0009-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90675-
dc.description.abstractMetabolic syndrome is one of the major factors to increase the incidence of heart failure. In our study, we compared plasma fatty acid compositions among heart failure patients with and without Metabolic syndrome. Fatty acid (FA) composition of plasma phospholipids was analyzed and the activities of desaturase were estimated as the ratio of substrate and product fatty acids in 85 stable heart failure patients. Fatty acid and estimated desaturase activities were further examined for their associations with Metabolic syndrome components. Heart failure patients with Metabolic syndrome showed significant changes in fatty acid composition in comparison to those without Metabolic syndrome, which had a decreased proportion of lauric acid (C12:0) and an increased proportion of dihomo-γ-linolenic acid (C20:3n-6). Also, estimated desaturase activities (D5D and D6D) were closely related to Metabolic syndrome condition among heart failure patients. The content of dihomo-γ-linolenic acid showed positive correlations with BMI, waist circumference, and plasma triglyceride levels. D6D were positively associated with plasma triglyceride levels, whereas D5D showed a negative correlation with plasma triglyceride levels and waist circumferences. The content of dihomo-γ-linolenic acid as well as estimated D6D and D5D were altered in heart failure patients with Metabolic syndrome.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePlasma phospholipid fatty acid composition and estimated desaturase activity in heart failure patients with metabolic syndrome-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentYonsei Cardiovascular Research Institute (심혈관연구소)-
dc.contributor.googleauthorSeungmin Lee-
dc.contributor.googleauthorHyun Ju Do-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorJi Hyung Chung-
dc.contributor.googleauthorEunju Park-
dc.contributor.googleauthorMin-Jeong Shin-
dc.identifier.doi22962535-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00037-
dc.contributor.localIdA03739-
dc.relation.journalcodeJ01316-
dc.identifier.eissn1880-5086-
dc.identifier.pmid22962535-
dc.subject.keyworddesaturase-
dc.subject.keyworddihomo-γ-linolenic acid-
dc.subject.keywordfatty acid-
dc.subject.keywordheart failure-
dc.subject.keywordmetabolic syndrome-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.alternativeNameChung, Ji Hyung-
dc.contributor.affiliatedAuthorKang, Seok Min-
dc.contributor.affiliatedAuthorChung, Ji Hyung-
dc.citation.volume51-
dc.citation.number2-
dc.citation.startPage150-
dc.citation.endPage155-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, Vol.51(2) : 150-155, 2012-
dc.identifier.rimsid33459-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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