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Urinary ketone is associated with the heart failure severity.

Authors
 Ji Hyung Chung  ;  Jin-Sup Kim  ;  Oh Yoen Kim  ;  Seok-Min Kang  ;  Geum-Sook Hwang  ;  Min-Jeong Shin 
Citation
 CLINICAL BIOCHEMISTRY, Vol.45(18) : 1697-1699, 2012 
Journal Title
CLINICAL BIOCHEMISTRY
ISSN
 0009-9120 
Issue Date
2012
MeSH
Aged ; Female ; Heart Failure/classification ; Heart Failure/diagnostic imaging ; Heart Failure/pathology* ; Heart Failure/urine* ; Humans ; Ketones/urine* ; Male ; New York ; Regression Analysis ; Severity of Illness Index ; Stroke Volume ; Ultrasonography
Keywords
Heart failure ; Urine ; Ketones ; Ejection fraction ; Echocardiography
Abstract
OBJECTIVES: To test the hypothesis that urinary metabolites characterizing heart failure (HF) are associated with the magnitude of echocardiographic measurements and ultimately the severity of HF.

DESIGN/METHODS: Patients with systolic HF (n=46) and control subjects (n=32) participated in this study. Patients with type 2 diabetes mellitus were excluded. Echocardiographic measurements were performed, and selected urinary metabolites were quantified.

RESULTS: Urinary levels of acetate (p<0.05), acetone (p<0.01), cytosine (p<0.001), methylmalonate (p<0.001), and phenylacetylglycine (p<0.01) were significantly higher, while 1-methylnicotinamide (p<0.05) were significantly lower in HF patients than in controls. There were significant differences in E/E' (p<0.05), urinary levels of acetate (p<0.005), acetoacetate (p<0.05), acetone (p<0.05) and ketones (p<0.01) according to the New York Heart Association (NYHA) classification in HF patients. Multiple linear regression analysis revealed that urinary ketones were found to be independent factors for both left ventricular ejection fraction and E/E' after adjusting for confounders.

CONCLUSION: Our results showed that urinary levels of ketone bodies are associated with the magnitude of echocardiographic parameters.
Full Text
http://www.sciencedirect.com/science/article/pii/S0009912012004936
DOI
22935565
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Chung, Ji Hyung(정지형)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90008
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