Cited 13 times in
Urinary ketone is associated with the heart failure severity
DC Field | Value | Language |
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dc.contributor.author | 강석민 | - |
dc.contributor.author | 정지형 | - |
dc.date.accessioned | 2014-12-19T16:41:30Z | - |
dc.date.available | 2014-12-19T16:41:30Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0009-9120 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90008 | - |
dc.description.abstract | OBJECTIVES: To test the hypothesis that urinary metabolites characterizing heart failure (HF) are associated with the magnitude of echocardiographic measurements and ultimately the severity of HF. DESIGN/METHODS: Patients with systolic HF (n=46) and control subjects (n=32) participated in this study. Patients with type 2 diabetes mellitus were excluded. Echocardiographic measurements were performed, and selected urinary metabolites were quantified. RESULTS: Urinary levels of acetate (p<0.05), acetone (p<0.01), cytosine (p<0.001), methylmalonate (p<0.001), and phenylacetylglycine (p<0.01) were significantly higher, while 1-methylnicotinamide (p<0.05) were significantly lower in HF patients than in controls. There were significant differences in E/E' (p<0.05), urinary levels of acetate (p<0.005), acetoacetate (p<0.05), acetone (p<0.05) and ketones (p<0.01) according to the New York Heart Association (NYHA) classification in HF patients. Multiple linear regression analysis revealed that urinary ketones were found to be independent factors for both left ventricular ejection fraction and E/E' after adjusting for confounders. CONCLUSION: Our results showed that urinary levels of ketone bodies are associated with the magnitude of echocardiographic parameters. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CLINICAL BIOCHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heart Failure/classification | - |
dc.subject.MESH | Heart Failure/diagnostic imaging | - |
dc.subject.MESH | Heart Failure/pathology* | - |
dc.subject.MESH | Heart Failure/urine* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ketones/urine* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | New York | - |
dc.subject.MESH | Regression Analysis | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Stroke Volume | - |
dc.subject.MESH | Ultrasonography | - |
dc.title | Urinary ketone is associated with the heart failure severity | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Yonsei Cardiovascular Research Institute (심혈관연구소) | - |
dc.contributor.googleauthor | Ji Hyung Chung | - |
dc.contributor.googleauthor | Jin-Sup Kim | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Geum-Sook Hwang | - |
dc.contributor.googleauthor | Min-Jeong Shin | - |
dc.identifier.doi | 10.1016/j.clinbiochem.2012.08.013 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00037 | - |
dc.contributor.localId | A03739 | - |
dc.relation.journalcode | J00561 | - |
dc.identifier.eissn | 1873-2933 | - |
dc.identifier.pmid | 22935565 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0009912012004936 | - |
dc.subject.keyword | Heart failure | - |
dc.subject.keyword | Urine | - |
dc.subject.keyword | Ketones | - |
dc.subject.keyword | Ejection fraction | - |
dc.subject.keyword | Echocardiography | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.alternativeName | Chung, Ji Hyung | - |
dc.contributor.affiliatedAuthor | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | Chung, Ji Hyung | - |
dc.citation.volume | 45 | - |
dc.citation.number | 18 | - |
dc.citation.startPage | 1697 | - |
dc.citation.endPage | 1699 | - |
dc.identifier.bibliographicCitation | CLINICAL BIOCHEMISTRY, Vol.45(18) : 1697-1699, 2012 | - |
dc.identifier.rimsid | 32304 | - |
dc.type.rims | ART | - |
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