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Urinary ketone is associated with the heart failure severity.

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dc.contributor.author강석민-
dc.contributor.author정지형-
dc.date.accessioned2014-12-19T16:41:30Z-
dc.date.available2014-12-19T16:41:30Z-
dc.date.issued2012-
dc.identifier.issn0009-9120-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90008-
dc.description.abstractOBJECTIVES: To test the hypothesis that urinary metabolites characterizing heart failure (HF) are associated with the magnitude of echocardiographic measurements and ultimately the severity of HF. DESIGN/METHODS: Patients with systolic HF (n=46) and control subjects (n=32) participated in this study. Patients with type 2 diabetes mellitus were excluded. Echocardiographic measurements were performed, and selected urinary metabolites were quantified. RESULTS: Urinary levels of acetate (p<0.05), acetone (p<0.01), cytosine (p<0.001), methylmalonate (p<0.001), and phenylacetylglycine (p<0.01) were significantly higher, while 1-methylnicotinamide (p<0.05) were significantly lower in HF patients than in controls. There were significant differences in E/E' (p<0.05), urinary levels of acetate (p<0.005), acetoacetate (p<0.05), acetone (p<0.05) and ketones (p<0.01) according to the New York Heart Association (NYHA) classification in HF patients. Multiple linear regression analysis revealed that urinary ketones were found to be independent factors for both left ventricular ejection fraction and E/E' after adjusting for confounders. CONCLUSION: Our results showed that urinary levels of ketone bodies are associated with the magnitude of echocardiographic parameters.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCLINICAL BIOCHEMISTRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHFemale-
dc.subject.MESHHeart Failure/classification-
dc.subject.MESHHeart Failure/diagnostic imaging-
dc.subject.MESHHeart Failure/pathology*-
dc.subject.MESHHeart Failure/urine*-
dc.subject.MESHHumans-
dc.subject.MESHKetones/urine*-
dc.subject.MESHMale-
dc.subject.MESHNew York-
dc.subject.MESHRegression Analysis-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHStroke Volume-
dc.subject.MESHUltrasonography-
dc.titleUrinary ketone is associated with the heart failure severity.-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentYonsei Cardiovascular Research Institute (심혈관연구소)-
dc.contributor.googleauthorJi Hyung Chung-
dc.contributor.googleauthorJin-Sup Kim-
dc.contributor.googleauthorOh Yoen Kim-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorGeum-Sook Hwang-
dc.contributor.googleauthorMin-Jeong Shin-
dc.identifier.doi22935565-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00037-
dc.contributor.localIdA03739-
dc.relation.journalcodeJ00561-
dc.identifier.eissn1873-2933-
dc.identifier.pmid22935565-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0009912012004936-
dc.subject.keywordHeart failure-
dc.subject.keywordUrine-
dc.subject.keywordKetones-
dc.subject.keywordEjection fraction-
dc.subject.keywordEchocardiography-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.alternativeNameChung, Ji Hyung-
dc.contributor.affiliatedAuthorKang, Seok Min-
dc.contributor.affiliatedAuthorChung, Ji Hyung-
dc.citation.volume45-
dc.citation.number18-
dc.citation.startPage1697-
dc.citation.endPage1699-
dc.identifier.bibliographicCitationCLINICAL BIOCHEMISTRY, Vol.45(18) : 1697-1699, 2012-
dc.identifier.rimsid32304-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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