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The diagnostic values of ultrasound and ultrasound-guided fine needle aspiration in subcentimeter-sized thyroid nodules

Authors
 Hee Jung Moon  ;  Eunju Son  ;  Eun-Kyung Kim  ;  Jung Hyun Yoon  ;  Jin Young Kwak 
Citation
 ANNALS OF SURGICAL ONCOLOGY, Vol.19(1) : 52-59, 2012 
Journal Title
 ANNALS OF SURGICAL ONCOLOGY 
ISSN
 1068-9265 
Issue Date
2012
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy, Fine-Needle ; Carcinoma, Papillary/diagnosis* ; Carcinoma, Papillary/surgery ; Child ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Sensitivity and Specificity ; Thyroid Neoplasms/diagnosis* ; Thyroid Neoplasms/surgery ; Thyroid Nodule/diagnosis* ; Thyroid Nodule/surgery ; Thyroidectomy ; Ultrasonics* ; Young Adult
Keywords
Nodule ; Papillary Thyroid Carcinoma ; Fine Needle Aspiration ; Diagnostic Performance ; Thyroid Nodule
Abstract
BACKGROUND: The diagnostic performances of ultrasound (US) examination and US-guided fine needle aspiration (US-FNA) were investigated in thyroid nodules ≤10 mm in size. METHODS: From April 2006 to December 2006, 1440 nodules ≤10 mm in size in 1403 patients (mean age, 49.3 years; range, 10-84 years) underwent US and US-FNA. The association between nodule size and inadequate specimen was investigated using the Cochran-Armitage trend test and multivariate logistic regression analysis. To evaluate the diagnostic performances of US and US-FNA, we selected 852 nodules that had undergone surgery, follow-up US-FNA, or follow-up US. A receiver operating characteristic (ROC) curve analysis was used to determine the accuracies of US and US-FNA. RESULTS: Of 1440 nodules, 256 (17.8%) yielded inadequate specimens. As the nodule size increased, the rate of inadequate specimens decreased (P < 0.001). A size of 6 mm demonstrated statistical significance between inadequate and adequate specimens (P < 0.001). The diagnostic accuracy of US was slightly improved as nodule size increased. The false positive rate of US examination was higher in nodules ≤6 mm compared with that of nodules >6 mm in size (P = 0.049). However, US-FNA demonstrated high diagnostic performance in all nodules with adequate specimen. CONCLUSIONS: The inadequate specimens of US-FNA and false positives for US examinations increased as nodule size decreased. However, US-FNA demonstrated good diagnostic accuracy, assuming the specimen was adequate.
Full Text
http://link.springer.com/article/10.1245%2Fs10434-011-1813-1
DOI
21638096
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89537
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