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Association between EPCs count and rate of coronary revascularization in asymptomatic type 2 diabetic patients

 Hyun Min Kim  ;  Kwang Joon Kim  ;  Jae Hoon Moon  ;  Hye-Jeong Lee  ;  Min Kyung Chae  ;  Hyuk-Jae Chang  ;  Eun Seok Kang  ;  Bong Soo Cha  ;  Hyun Chul Lee  ;  Young Jin Kim 
 ACTA DIABETOLOGICA, Vol.49(6) : 413-420, 2012 
Journal Title
Issue Date
Adult ; Aged ; Asymptomatic Diseases/epidemiology ; Case-Control Studies ; Cell Count ; Coronary Angiography ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/etiology ; Coronary Artery Disease/surgery ; Diabetes Mellitus, Type 2/complications* ; Diabetes Mellitus, Type 2/epidemiology* ; Diabetes Mellitus, Type 2/pathology ; Diabetes Mellitus, Type 2/surgery ; Diabetic Angiopathies/epidemiology ; Diabetic Angiopathies/surgery ; Endothelial Cells/pathology* ; Female ; Humans ; Male ; Middle Aged ; Myocardial Revascularization/statistics & numerical data* ; Stem Cells/pathology*
Endothelial progenitor cells ; Cardiovascular magnetic resonance ; Coronary artery disease ; Revascularization ; Type 2 diabetes mellitus
Coronary arterial disease (CAD) is common in diabetic patients, and endothelial progenitor cells (EPCs) are considered a surrogate marker for CAD, but controversies regarding this issue still remain. We investigated the potential clinical role of EPCs during coronary screening in asymptomatic type 2 diabetic patients screened with cardiovascular magnetic resonance (CMR). A total of 100 asymptomatic type 2 diabetic subjects (51 men and 49 women) were enrolled. Clinical and laboratory parameters, including EPCs (CD34(+)/CD133(+)/VEGFR-2(+)) count, were evaluated and CMR was performed. A total of 51 patients [silent myocardial infarction (n = 3), inducible ischemia (n = 11), suspected CAD (n = 37)] had abnormal finding on CMR. Of the 20 patients who later underwent invasive coronary angiography, 8 were treated with revascularization. Fifty-one subjects with abnormal finding on CMR were divided into two groups [subjects with revascularization (group I, n = 8) vs. without revascularization (group II, n = 43)]. Group I had a significantly increased EPCs level than group II (833 vs. 415, P = 0.027). Multivariate logistic regression analysis revealed that an increased EPCs level (OR = 1.003, P = 0.024) and a high body-mass index (OR = 1.907, P = 0.028) were independently correlated with revascularization. In our study, increased EPCs count is associated with performing revascularization in asymptomatic type 2 diabetic patients, and that increased EPCs count can provide clinically important information while performing intervention.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kwang Joon(김광준) ORCID logo https://orcid.org/0000-0002-5554-8255
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Kim, Hyun Min(김현민)
Moon, Jae Hoon(문재훈)
Lee, Byung Wan(이병완) ORCID logo https://orcid.org/0000-0002-9899-4992
Lee, Hyun Chul(이현철)
Lee, Hye Jeong(이혜정) ORCID logo https://orcid.org/0000-0003-4349-9174
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Chae, Min Kyung(채민경)
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