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Association between EPCs count and rate of coronary revascularization in asymptomatic type 2 diabetic patients
DC Field | Value | Language |
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dc.contributor.author | 장혁재 | - |
dc.contributor.author | 차봉수 | - |
dc.contributor.author | 채민경 | - |
dc.contributor.author | 강은석 | - |
dc.contributor.author | 김영진 | - |
dc.contributor.author | 김현민 | - |
dc.contributor.author | 문재훈 | - |
dc.contributor.author | 이병완 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 이혜정 | - |
dc.contributor.author | 김광준 | - |
dc.date.accessioned | 2014-12-19T16:20:54Z | - |
dc.date.available | 2014-12-19T16:20:54Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0940-5429 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89358 | - |
dc.description.abstract | Coronary arterial disease (CAD) is common in diabetic patients, and endothelial progenitor cells (EPCs) are considered a surrogate marker for CAD, but controversies regarding this issue still remain. We investigated the potential clinical role of EPCs during coronary screening in asymptomatic type 2 diabetic patients screened with cardiovascular magnetic resonance (CMR). A total of 100 asymptomatic type 2 diabetic subjects (51 men and 49 women) were enrolled. Clinical and laboratory parameters, including EPCs (CD34(+)/CD133(+)/VEGFR-2(+)) count, were evaluated and CMR was performed. A total of 51 patients [silent myocardial infarction (n = 3), inducible ischemia (n = 11), suspected CAD (n = 37)] had abnormal finding on CMR. Of the 20 patients who later underwent invasive coronary angiography, 8 were treated with revascularization. Fifty-one subjects with abnormal finding on CMR were divided into two groups [subjects with revascularization (group I, n = 8) vs. without revascularization (group II, n = 43)]. Group I had a significantly increased EPCs level than group II (833 vs. 415, P = 0.027). Multivariate logistic regression analysis revealed that an increased EPCs level (OR = 1.003, P = 0.024) and a high body-mass index (OR = 1.907, P = 0.028) were independently correlated with revascularization. In our study, increased EPCs count is associated with performing revascularization in asymptomatic type 2 diabetic patients, and that increased EPCs count can provide clinically important information while performing intervention. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ACTA DIABETOLOGICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Asymptomatic Diseases/epidemiology | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cell Count | - |
dc.subject.MESH | Coronary Angiography | - |
dc.subject.MESH | Coronary Artery Disease/epidemiology | - |
dc.subject.MESH | Coronary Artery Disease/etiology | - |
dc.subject.MESH | Coronary Artery Disease/surgery | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/complications* | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/epidemiology* | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/pathology | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/surgery | - |
dc.subject.MESH | Diabetic Angiopathies/epidemiology | - |
dc.subject.MESH | Diabetic Angiopathies/surgery | - |
dc.subject.MESH | Endothelial Cells/pathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocardial Revascularization/statistics & numerical data* | - |
dc.subject.MESH | Stem Cells/pathology* | - |
dc.title | Association between EPCs count and rate of coronary revascularization in asymptomatic type 2 diabetic patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hyun Min Kim | - |
dc.contributor.googleauthor | Kwang Joon Kim | - |
dc.contributor.googleauthor | Jae Hoon Moon | - |
dc.contributor.googleauthor | Hye-Jeong Lee | - |
dc.contributor.googleauthor | Min Kyung Chae | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Bong Soo Cha | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.contributor.googleauthor | Young Jin Kim | - |
dc.identifier.doi | 22160247 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03490 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A04016 | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A01110 | - |
dc.contributor.localId | A01378 | - |
dc.contributor.localId | A02796 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03320 | - |
dc.contributor.localId | A00727 | - |
dc.contributor.localId | A00317 | - |
dc.relation.journalcode | J00013 | - |
dc.identifier.eissn | 1432-5233 | - |
dc.identifier.pmid | 22160247 | - |
dc.identifier.url | http://dx.doi.org/10.1007/s00592-011-0360-3 | - |
dc.subject.keyword | Endothelial progenitor cells | - |
dc.subject.keyword | Cardiovascular magnetic resonance | - |
dc.subject.keyword | Coronary artery disease | - |
dc.subject.keyword | Revascularization | - |
dc.subject.keyword | Type 2 diabetes mellitus | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.alternativeName | Chae, Min Kyung | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Kim, Young Jin | - |
dc.contributor.alternativeName | Kim, Hyun Min | - |
dc.contributor.alternativeName | Moon, Jae Hoon | - |
dc.contributor.alternativeName | Lee, Byung Wan | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Lee, Hye Jeong | - |
dc.contributor.affiliatedAuthor | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Chae, Min Kyung | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Min | - |
dc.contributor.affiliatedAuthor | Moon, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Byung Wan | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Lee, Hye Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Young Jin | - |
dc.contributor.affiliatedAuthor | Kim, Kwang Joon | - |
dc.citation.volume | 49 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 413 | - |
dc.citation.endPage | 420 | - |
dc.identifier.bibliographicCitation | ACTA DIABETOLOGICA, Vol.49(6) : 413-420, 2012 | - |
dc.identifier.rimsid | 34556 | - |
dc.type.rims | ART | - |
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