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Discovery of DiPeptidyl Peptidase-4 Gene Variants and the Associations with Efficacy of Vildagliptin in Patients with Type 2 Diabetes - A Pilot Study

Authors
 Obin Kwon  ;  Eun Yeong Choe  ;  Younjeong Choi  ;  Hyun Min Kim  ;  Hye Jin Wang  ;  Hyangkyu Lee  ;  Chul Hoon Kim  ;  Eun Seok Kang 
Citation
 Journal of Diabetes & Metabolism, Vol.S13(006) : 1-6, 2013 
Journal Title
 Journal of Diabetes & Metabolism 
ISSN
 2155-6156 
Issue Date
2013
Abstract
Background: The dipeptidyl peptidase-4 (DPP4) inhibitors have become widely used antidiabetic medication. They control glycemia by interacting with serum DPP4 to interfere catalyzation of incretins. The aim of this pilot study was to discover the DPP4 polymorphisms that could affect the efficacy of vildagliptin, a DPP-4 inhibitor in diabetic patients. Methods: Genetic variations in DPP4 were identified in 48 patients with type 2 diabetes who received vildagliptin treatment at least 12 weeks following metformin monotherapy. Luciferase assay was performed to estimate the effect of the regulatory single nucleotide polymorphism (SNP) on expression of DPP4. Results: Eight tagging SNPs were genotyped in a sample of 24 patients. Additional sample of 24 patients was used to discover further regulatory SNPs and coding SNPs. In all 48 patients, responders (degree of HbA1c and/or fasting glucose level decrease greater than 10% of baseline after 12 weeks of vildagliptin add-on treatment) did not show any significant difference in selected six DPP4 polymorphisms from non-responders. DPP4 expression was not different according to g.-234A/C in luciferase assay. Conclusion: Our pilot study could not find any significant genetic variant which is associated with vildagliptin response in patients with type 2 diabetes. Further studies in large population are warranted.
Files in This Item:
T201305915.pdf Download
DOI
10.4172/2155-6156.S13-006
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
강은석(Kang, Eun Seok) ORCID logo https://orcid.org/0000-0002-0364-4675
권오빈(Kwon, O Bin)
김철훈(Kim, Chul Hoon) ORCID logo https://orcid.org/0000-0002-7360-429X
김현민(Kim, Hyun Min)
왕혜진(Wang, Hye Jin)
이향규(Lee, Hyang Kyu) ORCID logo https://orcid.org/0000-0002-0821-6020
최연정(Choi, Youn Jeong)
최은영(Choe, Eun Yeong)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89290
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