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The Transcription Factor Protein Sox11 Enhances Early Osteoblast Differentiation by Facilitating Proliferation and the Survival of Mesenchymal and Osteoblast Progenitors

 Jogeswar Gadi  ;  Seung-Hyun Jung  ;  Min-Jung Lee  ;  Ajita Jami  ;  Kalyani Ruthala  ;  Kyoung-Min Kim  ;  Nam-Hoon Cho  ;  Han-Sung Jung  ;  Cheol-Hee Kim  ;  Sung-Kil Lim 
 JOURNAL OF BIOLOGICAL CHEMISTRY, Vol.288(35) : 25400-25413, 2013 
Journal Title
Issue Date
Animals ; Cell Differentiation/physiology* ; Cell Line ; Cell Proliferation* ; Cell Survival/physiology ; Core Binding Factor Alpha 1 Subunit/genetics ; Core Binding Factor Alpha 1 Subunit/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Humans ; Mesenchymal Stromal Cells/cytology ; Mesenchymal Stromal Cells/metabolism* ; Mice ; Osteoblasts/cytology ; Osteoblasts/metabolism* ; SOXC Transcription Factors/genetics ; SOXC Transcription Factors/metabolism* ; Sp7 Transcription Factor ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Zebrafish/embryology ; Zebrafish/genetics
Apoptosis ; Bone ; Hippo Signaling ; Mesenchymal Stem Cells ; Osteoblasts ; Osteocyte ; Osteogenesis ; Osterix ; Runx2 ; Sox11
Sox11 deletion mice are known to exhibit developmental defects of craniofacial skeletal malformations, asplenia, and hypoplasia of the lung, stomach, and pancreas. Despite the importance of Sox11 in the developing skeleton, the role of Sox11 in osteogenesis has not been studied yet. In this study, we identified that Sox11 is an important transcription factor for regulating the proliferation and survival of osteoblast precursor cells as well as the self-renewal potency of mesenchymal progenitor cells via up-regulation of Tead2. Furthermore, Sox11 also plays an important role in the segregation of functional osteoblast lineage progenitors from osteochondrogenic progenitors. Facilitation of osteoblast differentiation from mesenchymal cells was achieved by enhanced expression of the osteoblast lineage specific transcription factors Runx2 and Osterix. Morpholino-targeted disruption of Sox11 in zebrafish impaired organogenesis, including the bones, which were under mineralized. These results indicated that Sox11 plays a crucial role in the proliferation and survival of mesenchymal and osteoblast precursors by Tead2, and osteogenic differentiation by regulating Runx2 and Osterix.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute of Endocrinology (내분비연구소) > 1. Journal Papers
Yonsei Authors
Gadi, Jogeswar(가디죠게스)
Ajita Jami(아지타자미)
Lee, Min Jung(이민정)
Lim, Sung Kil(임승길)
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
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