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Therapeutic effects of repetitive transcranial magnetic stimulation in an animal model of Parkinson's disease

 Ji Yong Lee  ;  Sung Hoon Kim  ;  Ah-Ra Ko  ;  Jin Suk Lee  ;  Ji Hea Yu  ;  Jung Hwa Seo  ;  Byung Pil Cho  ;  Sung-Rae Cho 
 BRAIN RESEARCH, Vol.1537 : 290-302, 2013 
Journal Title
Issue Date
Animals ; Behavior, Animal/physiology ; Brain-Derived Neurotrophic Factor/metabolism ; Corpus Striatum/metabolism* ; Corpus Striatum/physiology ; Disease Models, Animal ; Dopamine/metabolism ; Glial Cell Line-Derived Neurotrophic Factor/metabolism ; Male ; Neurons/metabolism* ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Parkinson Disease/therapy* ; Rats ; Rats, Sprague-Dawley ; Substantia Nigra/metabolism* ; Substantia Nigra/pathology ; Transcranial Magnetic Stimulation* ; Up-Regulation
Dopaminergic neuron ; Neurotrophic/growth factor ; Parkinson's disease ; Repetitive transcranial magnetic stimulation
Repetitive transcranial magnetic stimulation (rTMS) is used to treat neurological diseases such as stroke and Parkinson's disease (PD). Although rTMS has been used clinically, its underlying therapeutic mechanism remains unclear. The objective of the present study was to clarify the neuroprotective effect and therapeutic mechanism of rTMS in an animal model of PD. Adult Sprague-Dawley rats were unilaterally injected with 6-hydroxydopamine (6-OHDA) into the right striatum. Rats with PD were then treated with rTMS (circular coil, 10 Hz, 20 min/day) daily for 4 weeks. Behavioral assessments such as amphetamine-induced rotational test and treadmill locomotion test were performed, and the dopaminergic (DA) neurons of substantia nigra pas compacta (SNc) and striatum were histologically examined. Expression of neurotrophic/growth factors was also investigated by multiplex ELISA, western blotting analysis and immunohistochemistry 4 weeks after rTMS application. Among the results, the number of amphetamine-induced rotations was significantly lower in the rTMS group than in the control group at 4 weeks post-treatment. Treadmill locomotion was also significantly improved in the rTMS-treated rats. Tyrosine hydroxylase-positive DA neurons and DA fibers in rTMS group rats were greater than those in untreated group in both ipsilateral SNc and striatum, respectively. The expression levels of brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, platelet-derived growth factor, and vascular endothelial growth factor were elevated in both the 6-OHDA-injected hemisphere and the SNc of the rTMS-treated rats. In conclusion, rTMS treatment improved motor functions and survival of DA neurons, suggesting that the neuroprotective effect of rTMS treatment might be induced by upregulation of neurotrophic/growth factors in the PD animal model.
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1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Seo, Jung Hwa(서정화)
Yu, Ji Hea(유지혜)
Cho, Sung-Rae(조성래) ORCID logo https://orcid.org/0000-0003-1429-2684
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