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Plasma osteoprotegerin levels increase with the severity of cerebral artery atherosclerosis

 Jinkwon Kim  ;  Tae-Jin Song  ;  Seung-Hee Yang  ;  Ok-Hee Lee  ;  Hyo Suk Nam  ;  Young Dae Kim  ;  Eun Hee Kim  ;  Hye Sun Lee  ;  Chung Mo Nam  ;  Ji Hoe Heo 
 CLINICAL BIOCHEMISTRY, Vol.46(12) : 1036-1040, 2013 
Journal Title
Issue Date
Atherosclerosis/blood* ; Atherosclerosis/pathology* ; Cerebral Arteries/pathology* ; Female ; Humans ; Male ; Middle Aged ; Osteoprotegerin/blood* ; ROC Curve ; Severity of Illness Index*
Atherosclerosis ; CI ; CT ; CTA ; Cerebral artery ; Cerebral infarction ; DSA ; IQR ; MMP ; MR ; MRA ; OPG ; OR ; Osteoprotegerin ; RANKL ; SD ; Stroke ; TNF ; TRAIL ; Tumor necrosis factor ; computed tomographic angiography ; computed tomography ; confidence interval ; digital subtraction angiography ; eGFR ; estimated glomerular filtration rate ; high sensitive C-reactive protein ; hs-CRP ; interquartile range ; magnetic resonance ; magnetic resonance angiography ; matrix metalloproteinases ; odds ratio ; osteoprotegerin ; receptor activator of nucleus factor-κB ligand ; standard deviation ; tumor necrosis factor ; tumor necrosis factor-related apoptosis-inducing ligand
OBJECTIVES: Osteoprotegerin (OPG) is a member of the tumor necrosis factor receptor superfamily and suggested as a marker of atherosclerosis. We investigated whether plasma OPG levels were associated with the presence and severity of cerebral atherosclerosis. DESIGN AND METHODS: We used an enzyme-linked immunosorbent assay to measure the plasma OPG levels of 107 patients with acute cerebral infarction. We compared the plasma OPG levels according to the presence and number of arteries with cerebral atherosclerosis (≥ 50% stenosis). RESULTS: Of 107 patients, 73 (68.2%) had cerebral atherosclerosis. OPG levels were increased in patients with cerebral atherosclerosis (374.69 ± 206.48 vs 261.17 ± 166.91 pg/mL, p=0.006). OPG levels showed positive correlation with the number of cerebral arteries with atherosclerosis (Spearman's rho=0.342, p<0.001). After adjustment for vascular risk factors, OPG>229.9 pg/mL was independently associated with the presence [OR 4.61, 95% CI 1.57-13.55, p=0.005, binary logistic regression] of cerebral atherosclerosis and number [OR 3.20, 95% CI 1.26-8.12, p=0.014, ordinal logistic regression] of arteries with cerebral atherosclerosis. CONCLUSIONS: Plasma OPG levels were significantly associated with the presence and severity of cerebral atherosclerosis. This finding suggests that plasma OPG might have a role in cerebral atherosclerosis.
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Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Dae(김영대) ORCID logo https://orcid.org/0000-0001-5750-2616
Kim, Jinkwon(김진권) ORCID logo https://orcid.org/0000-0003-0156-9736
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Song, Tae Jin(송태진)
Yang, Seung Hee(양승희)
Lee, Ok Hee(이옥희)
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
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