Cited 22 times in
Plasma osteoprotegerin levels increase with the severity of cerebral artery atherosclerosis
DC Field | Value | Language |
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dc.contributor.author | 김영대 | - |
dc.contributor.author | 김진권 | - |
dc.contributor.author | 남정모 | - |
dc.contributor.author | 남효석 | - |
dc.contributor.author | 송태진 | - |
dc.contributor.author | 양승희 | - |
dc.contributor.author | 이옥희 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 허지회 | - |
dc.date.accessioned | 2014-12-18T09:19:47Z | - |
dc.date.available | 2014-12-18T09:19:47Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0009-9120 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87968 | - |
dc.description.abstract | OBJECTIVES: Osteoprotegerin (OPG) is a member of the tumor necrosis factor receptor superfamily and suggested as a marker of atherosclerosis. We investigated whether plasma OPG levels were associated with the presence and severity of cerebral atherosclerosis. DESIGN AND METHODS: We used an enzyme-linked immunosorbent assay to measure the plasma OPG levels of 107 patients with acute cerebral infarction. We compared the plasma OPG levels according to the presence and number of arteries with cerebral atherosclerosis (≥ 50% stenosis). RESULTS: Of 107 patients, 73 (68.2%) had cerebral atherosclerosis. OPG levels were increased in patients with cerebral atherosclerosis (374.69 ± 206.48 vs 261.17 ± 166.91 pg/mL, p=0.006). OPG levels showed positive correlation with the number of cerebral arteries with atherosclerosis (Spearman's rho=0.342, p<0.001). After adjustment for vascular risk factors, OPG>229.9 pg/mL was independently associated with the presence [OR 4.61, 95% CI 1.57-13.55, p=0.005, binary logistic regression] of cerebral atherosclerosis and number [OR 3.20, 95% CI 1.26-8.12, p=0.014, ordinal logistic regression] of arteries with cerebral atherosclerosis. CONCLUSIONS: Plasma OPG levels were significantly associated with the presence and severity of cerebral atherosclerosis. This finding suggests that plasma OPG might have a role in cerebral atherosclerosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CLINICAL BIOCHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Atherosclerosis/blood* | - |
dc.subject.MESH | Atherosclerosis/pathology* | - |
dc.subject.MESH | Cerebral Arteries/pathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Osteoprotegerin/blood* | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Severity of Illness Index* | - |
dc.title | Plasma osteoprotegerin levels increase with the severity of cerebral artery atherosclerosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Jinkwon Kim | - |
dc.contributor.googleauthor | Tae-Jin Song | - |
dc.contributor.googleauthor | Seung-Hee Yang | - |
dc.contributor.googleauthor | Ok-Hee Lee | - |
dc.contributor.googleauthor | Hyo Suk Nam | - |
dc.contributor.googleauthor | Young Dae Kim | - |
dc.contributor.googleauthor | Eun Hee Kim | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Chung Mo Nam | - |
dc.contributor.googleauthor | Ji Hoe Heo | - |
dc.identifier.doi | 10.1016/j.clinbiochem.2013.05.048 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00702 | - |
dc.contributor.localId | A01012 | - |
dc.contributor.localId | A01264 | - |
dc.contributor.localId | A01273 | - |
dc.contributor.localId | A02073 | - |
dc.contributor.localId | A02296 | - |
dc.contributor.localId | A02970 | - |
dc.contributor.localId | A04369 | - |
dc.contributor.localId | A03312 | - |
dc.relation.journalcode | J00561 | - |
dc.identifier.eissn | 1873-2933 | - |
dc.identifier.pmid | 23726804 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0009912013002440 | - |
dc.subject.keyword | Atherosclerosis | - |
dc.subject.keyword | CI | - |
dc.subject.keyword | CT | - |
dc.subject.keyword | CTA | - |
dc.subject.keyword | Cerebral artery | - |
dc.subject.keyword | Cerebral infarction | - |
dc.subject.keyword | DSA | - |
dc.subject.keyword | IQR | - |
dc.subject.keyword | MMP | - |
dc.subject.keyword | MR | - |
dc.subject.keyword | MRA | - |
dc.subject.keyword | OPG | - |
dc.subject.keyword | OR | - |
dc.subject.keyword | Osteoprotegerin | - |
dc.subject.keyword | RANKL | - |
dc.subject.keyword | SD | - |
dc.subject.keyword | Stroke | - |
dc.subject.keyword | TNF | - |
dc.subject.keyword | TRAIL | - |
dc.subject.keyword | Tumor necrosis factor | - |
dc.subject.keyword | computed tomographic angiography | - |
dc.subject.keyword | computed tomography | - |
dc.subject.keyword | confidence interval | - |
dc.subject.keyword | digital subtraction angiography | - |
dc.subject.keyword | eGFR | - |
dc.subject.keyword | estimated glomerular filtration rate | - |
dc.subject.keyword | high sensitive C-reactive protein | - |
dc.subject.keyword | hs-CRP | - |
dc.subject.keyword | interquartile range | - |
dc.subject.keyword | magnetic resonance | - |
dc.subject.keyword | magnetic resonance angiography | - |
dc.subject.keyword | matrix metalloproteinases | - |
dc.subject.keyword | odds ratio | - |
dc.subject.keyword | osteoprotegerin | - |
dc.subject.keyword | receptor activator of nucleus factor-κB ligand | - |
dc.subject.keyword | standard deviation | - |
dc.subject.keyword | tumor necrosis factor | - |
dc.subject.keyword | tumor necrosis factor-related apoptosis-inducing ligand | - |
dc.contributor.alternativeName | Kim, Young Dae | - |
dc.contributor.alternativeName | Kim, Jin Kwon | - |
dc.contributor.alternativeName | Nam, Jung Mo | - |
dc.contributor.alternativeName | Nam, Hyo Suk | - |
dc.contributor.alternativeName | Song, Tae Jin | - |
dc.contributor.alternativeName | Yang, Seung Hee | - |
dc.contributor.alternativeName | Lee, Ok Hee | - |
dc.contributor.alternativeName | Lee, Hye Sun | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Kim, Young Dae | - |
dc.contributor.affiliatedAuthor | Kim, Jin Kwon | - |
dc.contributor.affiliatedAuthor | Nam, Jung Mo | - |
dc.contributor.affiliatedAuthor | Nam, Hyo Suk | - |
dc.contributor.affiliatedAuthor | Song, Tae Jin | - |
dc.contributor.affiliatedAuthor | Yang, Seung Hee | - |
dc.contributor.affiliatedAuthor | Lee, Ok Hee | - |
dc.contributor.affiliatedAuthor | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Lee, Hye Sun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 46 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1036 | - |
dc.citation.endPage | 1040 | - |
dc.identifier.bibliographicCitation | CLINICAL BIOCHEMISTRY, Vol.46(12) : 1036-1040, 2013 | - |
dc.identifier.rimsid | 32672 | - |
dc.type.rims | ART | - |
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