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Measurement depth enhancement in terahertz imaging of biological tissues

Authors
 Seung Jae Oh  ;  Sang-Hoon Kim  ;  Kiyoung Jeong  ;  Yeonji Park  ;  Yong-Min Huh  ;  Joo-Hiuk Son  ;  Jin-Suck Suh 
Citation
 Optics Express, Vol.21(18) : 21299-21305, 2013 
Journal Title
 Optics Express 
ISSN
 1094-4087 
Issue Date
2013
MeSH
Animals ; Ethanol/chemistry ; Glycerol/chemistry ; Image Enhancement* ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasms/diagnosis ; Petrolatum/chemistry ; Terahertz Imaging/methods* ; Time Factors ; Water/chemistry
Keywords
Animals ; Ethanol/chemistry ; Glycerol/chemistry ; Image Enhancement* ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasms/diagnosis ; Petrolatum/chemistry ; Terahertz Imaging/methods* ; Time Factors ; Water/chemistry
Abstract
We demonstrate the use of a THz penetration-enhancing agent (THz-PEA) to enhance the terahertz (THz) wave penetration depth in tissues. The THz-PEA is a biocompatible material having absorption lower than that of water, and it is easily absorbed into tissues. When using glycerol as a THz-PEA, the peak value of the THz signal which was transmitted through the fresh tissue and reflected by a metal target, was almost doubled compared to that of tissue without glycerol. THz time-of-flight imaging (B-scan) was used to display the sequential glycerol delivery images. Enhancement of the penetration depth was confirmed after an artificial tumor was located below fresh skin. We thus concluded that the THz-PEA technique can potentially be employed to enhance the image contrast of the abnormal lesions below the skin.
Full Text
http://www.opticsinfobase.org/oe/abstract.cfm?uri=oe-21-18-21299
DOI
10.1364/OE.21.021299
Appears in Collections:
5. Research Institutes (연구소) > Institute for Medical Convergence (연의-생공연 메디컬융합연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Hoon(김상훈)
Park, Yeon Ji(박연지)
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Oh, Seung Jae(오승재)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87664
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