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Analysis of tear cytokines and clinical correlations in Sjögren syndrome dry eye patients and non-Sjögren syndrome dry eye patients

Authors
 Sang Yeop Lee  ;  Soo Jung Han  ;  Sang Min Nam  ;  Sang Chul Yoon  ;  Ji Min Ahn  ;  Tae-Im Kim  ;  Eung Kweon Kim  ;  Kyoung Yul Seo 
Citation
 American Journal of Ophthalmology, Vol.156(2) : 247-253, 2013 
Journal Title
 American Journal of Ophthalmology 
ISSN
 0002-9394 
Issue Date
2013
MeSH
Adult ; Aged ; Cross-Sectional Studies ; Cytokines/metabolism* ; Eye Proteins/metabolism* ; Female ; Humans ; Immunoassay ; Middle Aged ; Prospective Studies ; Sjogren's Syndrome/diagnosis ; Sjogren's Syndrome/metabolism* ; Tears/chemistry ; Tears/metabolism*
Keywords
Adult ; Aged ; Cross-Sectional Studies ; Cytokines/metabolism* ; Eye Proteins/metabolism* ; Female ; Humans ; Immunoassay ; Middle Aged ; Prospective Studies ; Sjogren's Syndrome/diagnosis ; Sjogren's Syndrome/metabolism* ; Tears/chemistry ; Tears/metabolism*
Abstract
PURPOSE: To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non-Sjögren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated. DESIGN: Prospective cross-sectional study. METHODS: SS dry eye patients (n = 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n = 25; 40 eyes) and normal subjects (n = 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients. RESULTS: All cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF-α, and IL-6 were significantly different among the 3 groups (IL-17: SS > control P < .001, non-SS > control P = .042, SS > non-SS P < .001; TNF-α: SS > control P = .006, non-SS > control P = .034, SS > non-SS P = .029; IL-6: SS > control P = .002, non-SS > control P = .032, SS > non-SS P = .002). IL-17 was significantly correlated with TBUT (R = -0.22, P = .012) and Schirmer I test (R = -0.36, P = .027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R = -0.38, P = .02) in the non-SS group. CONCLUSIONS: Differences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome.
Full Text
http://www.sciencedirect.com/science/article/pii/S0002939413002316
DOI
10.1016/j.ajo.2013.04.003
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Kim, Tae Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
Nam, Sang Min(남상민)
Seo, Kyuong Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
Ahn, Ji Min(안지민)
Yoon, Sang Chul(윤상철) ORCID logo https://orcid.org/0000-0003-0454-9597
Lee, Sang Yeop(이상엽) ORCID logo https://orcid.org/0000-0002-3834-7953
Han, Soo Jung(한수정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87510
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