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Analysis of tear cytokines and clinical correlations in Sjögren syndrome dry eye patients and non-Sjögren syndrome dry eye patients

DC Field Value Language
dc.contributor.author김태임-
dc.contributor.author서경률-
dc.contributor.author윤상철-
dc.contributor.author한수정-
dc.contributor.author김응권-
dc.contributor.author이상엽-
dc.date.accessioned2014-12-18T09:05:17Z-
dc.date.available2014-12-18T09:05:17Z-
dc.date.issued2013-
dc.identifier.issn0002-9394-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87510-
dc.description.abstractPURPOSE: To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non-Sjögren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated. DESIGN: Prospective cross-sectional study. METHODS: SS dry eye patients (n = 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n = 25; 40 eyes) and normal subjects (n = 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients. RESULTS: All cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF-α, and IL-6 were significantly different among the 3 groups (IL-17: SS > control P < .001, non-SS > control P = .042, SS > non-SS P < .001; TNF-α: SS > control P = .006, non-SS > control P = .034, SS > non-SS P = .029; IL-6: SS > control P = .002, non-SS > control P = .032, SS > non-SS P = .002). IL-17 was significantly correlated with TBUT (R = -0.22, P = .012) and Schirmer I test (R = -0.36, P = .027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R = -0.38, P = .02) in the non-SS group. CONCLUSIONS: Differences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfAMERICAN JOURNAL OF OPHTHALMOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHCytokines/metabolism*-
dc.subject.MESHEye Proteins/metabolism*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunoassay-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHSjogren's Syndrome/diagnosis-
dc.subject.MESHSjogren's Syndrome/metabolism*-
dc.subject.MESHTears/chemistry-
dc.subject.MESHTears/metabolism*-
dc.titleAnalysis of tear cytokines and clinical correlations in Sjögren syndrome dry eye patients and non-Sjögren syndrome dry eye patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorSang Yeop Lee-
dc.contributor.googleauthorSoo Jung Han-
dc.contributor.googleauthorSang Min Nam-
dc.contributor.googleauthorSang Chul Yoon-
dc.contributor.googleauthorJi Min Ahn-
dc.contributor.googleauthorTae-Im Kim-
dc.contributor.googleauthorEung Kweon Kim-
dc.contributor.googleauthorKyoung Yul Seo-
dc.identifier.doi10.1016/j.ajo.2013.04.003-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01080-
dc.contributor.localIdA01252-
dc.contributor.localIdA01870-
dc.contributor.localIdA02263-
dc.contributor.localIdA02560-
dc.contributor.localIdA04295-
dc.contributor.localIdA00831-
dc.relation.journalcodeJ00097-
dc.identifier.eissn1879-1891-
dc.identifier.pmid23752063-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0002939413002316-
dc.subject.keywordAdult-
dc.subject.keywordAged-
dc.subject.keywordCross-Sectional Studies-
dc.subject.keywordCytokines/metabolism*-
dc.subject.keywordEye Proteins/metabolism*-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordImmunoassay-
dc.subject.keywordMiddle Aged-
dc.subject.keywordProspective Studies-
dc.subject.keywordSjogren's Syndrome/diagnosis-
dc.subject.keywordSjogren's Syndrome/metabolism*-
dc.subject.keywordTears/chemistry-
dc.subject.keywordTears/metabolism*-
dc.contributor.alternativeNameKim, Tae Im-
dc.contributor.alternativeNameSeo, Kyuong Yul-
dc.contributor.alternativeNameYoon, Sang Chul-
dc.contributor.alternativeNameHan, Soo Jung-
dc.contributor.alternativeNameKim, Eung Kweon-
dc.contributor.affiliatedAuthorKim, Tae Im-
dc.contributor.affiliatedAuthorSeo, Kyuong Yul-
dc.contributor.affiliatedAuthorYoon, Sang Chul-
dc.contributor.affiliatedAuthorHan, Soo Jung-
dc.contributor.affiliatedAuthorKim, Eung Kweon-
dc.rights.accessRightsnot free-
dc.citation.volume156-
dc.citation.number2-
dc.citation.startPage247-
dc.citation.endPage253-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF OPHTHALMOLOGY, Vol.156(2) : 247-253, 2013-
dc.identifier.rimsid34272-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Humanities and Social Sciences (인문사회의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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