Cited 162 times in
Analysis of tear cytokines and clinical correlations in Sjögren syndrome dry eye patients and non-Sjögren syndrome dry eye patients
DC Field | Value | Language |
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dc.contributor.author | 김태임 | - |
dc.contributor.author | 서경률 | - |
dc.contributor.author | 윤상철 | - |
dc.contributor.author | 한수정 | - |
dc.contributor.author | 김응권 | - |
dc.contributor.author | 이상엽 | - |
dc.date.accessioned | 2014-12-18T09:05:17Z | - |
dc.date.available | 2014-12-18T09:05:17Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0002-9394 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87510 | - |
dc.description.abstract | PURPOSE: To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non-Sjögren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated. DESIGN: Prospective cross-sectional study. METHODS: SS dry eye patients (n = 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n = 25; 40 eyes) and normal subjects (n = 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients. RESULTS: All cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF-α, and IL-6 were significantly different among the 3 groups (IL-17: SS > control P < .001, non-SS > control P = .042, SS > non-SS P < .001; TNF-α: SS > control P = .006, non-SS > control P = .034, SS > non-SS P = .029; IL-6: SS > control P = .002, non-SS > control P = .032, SS > non-SS P = .002). IL-17 was significantly correlated with TBUT (R = -0.22, P = .012) and Schirmer I test (R = -0.36, P = .027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R = -0.38, P = .02) in the non-SS group. CONCLUSIONS: Differences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF OPHTHALMOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Cytokines/metabolism* | - |
dc.subject.MESH | Eye Proteins/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoassay | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Sjogren's Syndrome/diagnosis | - |
dc.subject.MESH | Sjogren's Syndrome/metabolism* | - |
dc.subject.MESH | Tears/chemistry | - |
dc.subject.MESH | Tears/metabolism* | - |
dc.title | Analysis of tear cytokines and clinical correlations in Sjögren syndrome dry eye patients and non-Sjögren syndrome dry eye patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Sang Yeop Lee | - |
dc.contributor.googleauthor | Soo Jung Han | - |
dc.contributor.googleauthor | Sang Min Nam | - |
dc.contributor.googleauthor | Sang Chul Yoon | - |
dc.contributor.googleauthor | Ji Min Ahn | - |
dc.contributor.googleauthor | Tae-Im Kim | - |
dc.contributor.googleauthor | Eung Kweon Kim | - |
dc.contributor.googleauthor | Kyoung Yul Seo | - |
dc.identifier.doi | 10.1016/j.ajo.2013.04.003 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01080 | - |
dc.contributor.localId | A01252 | - |
dc.contributor.localId | A01870 | - |
dc.contributor.localId | A02263 | - |
dc.contributor.localId | A02560 | - |
dc.contributor.localId | A04295 | - |
dc.contributor.localId | A00831 | - |
dc.relation.journalcode | J00097 | - |
dc.identifier.eissn | 1879-1891 | - |
dc.identifier.pmid | 23752063 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0002939413002316 | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Cross-Sectional Studies | - |
dc.subject.keyword | Cytokines/metabolism* | - |
dc.subject.keyword | Eye Proteins/metabolism* | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Immunoassay | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Prospective Studies | - |
dc.subject.keyword | Sjogren's Syndrome/diagnosis | - |
dc.subject.keyword | Sjogren's Syndrome/metabolism* | - |
dc.subject.keyword | Tears/chemistry | - |
dc.subject.keyword | Tears/metabolism* | - |
dc.contributor.alternativeName | Kim, Tae Im | - |
dc.contributor.alternativeName | Seo, Kyuong Yul | - |
dc.contributor.alternativeName | Yoon, Sang Chul | - |
dc.contributor.alternativeName | Han, Soo Jung | - |
dc.contributor.alternativeName | Kim, Eung Kweon | - |
dc.contributor.affiliatedAuthor | Kim, Tae Im | - |
dc.contributor.affiliatedAuthor | Seo, Kyuong Yul | - |
dc.contributor.affiliatedAuthor | Yoon, Sang Chul | - |
dc.contributor.affiliatedAuthor | Han, Soo Jung | - |
dc.contributor.affiliatedAuthor | Kim, Eung Kweon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 156 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 247 | - |
dc.citation.endPage | 253 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF OPHTHALMOLOGY, Vol.156(2) : 247-253, 2013 | - |
dc.identifier.rimsid | 34272 | - |
dc.type.rims | ART | - |
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