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Relationship between leukoaraiosis and menopause in healthy middle-aged women

 Seok Kyo Seo  ;  Inkyung Jung  ;  Sang Min Lee  ;  SiHyun Cho  ;  Young Sik Choi  ;  Tae Sub Chung  ;  Byung Seok Lee 
 FERTILITY AND STERILITY, Vol.100(2) : 500-504, 2013 
Journal Title
Issue Date
Adult ; Age Factors ; Blood Pressure/physiology ; Cholesterol/blood ; Cohort Studies ; Female ; Health ; Humans ; Leukoaraiosis/diagnostic imaging ; Leukoaraiosis/epidemiology* ; Magnetic Resonance Imaging ; Menopause/physiology* ; Middle Aged ; Retrospective Studies ; Risk Factors ; Tomography, X-Ray Computed
Leukoaraiosis ; estrogen ; menopause
OBJECTIVE: To investigate the relationship between leukoaraiosis (LA) and menopause in healthy middle-aged women. DESIGN: A retrospective cohort study. SETTING: Health promotion center of a university hospital. PATIENT(S): We studied 262 healthy pre- and postmenopausal women ages 41-60 years who visited the health promotion center for a routine health checkup. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): LA is defined as diffuse white matter abnormalities on computed tomography or magnetic resonance imaging (MRI). LA was assessed by examining MRIs and using the rating scale of the Atherosclerosis Risk in Communities Study. Logistic regression analysis was performed to examine associations between LA and menopause. RESULT(S): Women with LA had a significantly higher age than women without LA. Elevated blood pressure (≥ 130/85 mm Hg) and low high-density lipoprotein cholesterol (<50 mg/dL) were frequent abnormal findings in women with LA. The proportion of menopause was significantly higher in women with LA than in those without LA. Menopause was independently associated with the presence of LA (adjusted odds ratio, 2.24; 95% confidence interval, 1.10, 4.60) after adjusting for confounding variables. CONCLUSION(S): Menopause was significantly associated with LA. Loss of estrogen may play an important role in the development of LA.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Lee, Sang Min(이상민)
Jung, Inkyung(정인경) ORCID logo https://orcid.org/0000-0003-3780-3213
Chung, Tae Sub(정태섭)
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
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