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Carbon Nanotube-Patterned Surface-Based Recognition of Carcinoembryonic Antigens in Tumor Cells for Cancer Diagnosis

Authors
 Taeyun Kwon  ;  Jinsung Park  ;  Gyudo Lee  ;  Kihwan Nam  ;  Yong-Min Huh  ;  Seong-Wook Lee  ;  Jaemoon Yang  ;  Chang Young Lee  ;  Kilho Eom 
Citation
 Journal of Physical Chemistry Letters, Vol.4(7) : 1126-1130, 2013 
Journal Title
 Journal of Physical Chemistry Letters 
ISSN
 1948-7185 
Issue Date
2013
Abstract
It has been of high significance to devise a biochemical analytical tool kit enabling the detection of few circulating tumor cells (CTCs) for early diagnosis of cancer. Despite recent effort made to detect few CTCs, it is still challenging to sense such cells with their low concentration and/or the minute amount of marker proteins expressed on few CTCs. In this work, we report the label-free recognition of carcinoembryonic antigens (CEAs) expressed on few CTCs by using a carbon nanotube (CNT) sensor coupled with scanning probe microscopy imaging for cancer diagnosis. It is shown that a CNT-patterned surface is able to specifically capture the CEA molecules in the whole cell lysate of CTCs with their concentration even up to 10–3 cells/mL. Our work sheds light on our bioassay based on a CNT-patterned surface for highly sensitive, label-free detection of marker proteins expressed on few tumor cells, which may open a new avenue in early diagnosis of cancer by providing a novel biochemical analysis tool kit.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86857
DOI
10.1021/jz400087m
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단)
Yonsei Authors
양재문(Yang, Jae Moon)
허용민(Huh, Yong Min)
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Full Text
http://pubs.acs.org/doi/abs/10.1021/jz400087m
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