Cited 16 times in
Carbon Nanotube-Patterned Surface-Based Recognition of Carcinoembryonic Antigens in Tumor Cells for Cancer Diagnosis
DC Field | Value | Language |
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dc.contributor.author | 양재문 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2014-12-18T08:44:10Z | - |
dc.date.available | 2014-12-18T08:44:10Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86857 | - |
dc.description.abstract | It has been of high significance to devise a biochemical analytical tool kit enabling the detection of few circulating tumor cells (CTCs) for early diagnosis of cancer. Despite recent effort made to detect few CTCs, it is still challenging to sense such cells with their low concentration and/or the minute amount of marker proteins expressed on few CTCs. In this work, we report the label-free recognition of carcinoembryonic antigens (CEAs) expressed on few CTCs by using a carbon nanotube (CNT) sensor coupled with scanning probe microscopy imaging for cancer diagnosis. It is shown that a CNT-patterned surface is able to specifically capture the CEA molecules in the whole cell lysate of CTCs with their concentration even up to 10–3 cells/mL. Our work sheds light on our bioassay based on a CNT-patterned surface for highly sensitive, label-free detection of marker proteins expressed on few tumor cells, which may open a new avenue in early diagnosis of cancer by providing a novel biochemical analysis tool kit. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF PHYSICAL CHEMISTRY LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Carbon Nanotube-Patterned Surface-Based Recognition of Carcinoembryonic Antigens in Tumor Cells for Cancer Diagnosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Taeyun Kwon | - |
dc.contributor.googleauthor | Jinsung Park | - |
dc.contributor.googleauthor | Gyudo Lee | - |
dc.contributor.googleauthor | Kihwan Nam | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seong-Wook Lee | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Chang Young Lee | - |
dc.contributor.googleauthor | Kilho Eom | - |
dc.identifier.doi | 10.1021/jz400087m | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04359 | - |
dc.contributor.localId | A02315 | - |
dc.relation.journalcode | J01707 | - |
dc.identifier.eissn | 1948-7185 | - |
dc.identifier.pmid | 26282031 | - |
dc.identifier.url | http://pubs.acs.org/doi/abs/10.1021/jz400087m | - |
dc.subject.keyword | aptamer | - |
dc.subject.keyword | cancer diagnosis | - |
dc.subject.keyword | carbon nanotube | - |
dc.subject.keyword | carcinoembryonic antigen | - |
dc.subject.keyword | circulating tumor cell | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 4 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1126 | - |
dc.citation.endPage | 1130 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHYSICAL CHEMISTRY LETTERS, Vol.4(7) : 1126-1130, 2013 | - |
dc.identifier.rimsid | 29248 | - |
dc.type.rims | ART | - |
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