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CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells

Authors
 Jungmin Park  ;  Minhee Ku  ;  Eunjung Kim  ;  Yeonji Park  ;  Yoochan Hong  ;  Seungjoo Haam  ;  Jae-Ho Cheong  ;  Eun Sung Park  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Jaemoon Yang 
Citation
 INTEGRATIVE BIOLOGY, Vol.5(4) : 669-672, 2013 
Journal Title
INTEGRATIVE BIOLOGY
ISSN
 1757-9694 
Issue Date
2013
Abstract
We describe a near-infrared-sensitive molecular imaging probe based on hydrogel complexes that can target a stem-like gastric cancer cell marker (CD44, a marker that often correlates with a poor prognosis in patients). Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. NIRSHs demonstrated good water-stability, biocompatibility, and specificity to CD44-expressing stem-like gastric cancer cells. Furthermore, NIR-sensitive in vivo imaging potentials of CD44-targetable NIRSHs for heterotopic/orthotopic xenograft mouse models were investigated.
Full Text
http://pubs.rsc.org/en/Content/ArticleLanding/2013/IB/c3ib20203h#!divAbstract
DOI
10.1039/c3ib20203h
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Min Hee(구민희) ORCID logo https://orcid.org/0000-0002-1674-1474
Park, Eun Sung(박은성)
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86740
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