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CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells

Authors
 Jungmin Park  ;  Minhee Ku  ;  Eunjung Kim  ;  Yeonji Park  ;  Yoochan Hong  ;  Seungjoo Haam  ;  Jae-Ho Cheong  ;  Eun Sung Park  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Jaemoon Yang 
Citation
 Integrative Biology, Vol.5(4) : 669-672, 2013 
Journal Title
 Integrative Biology 
ISSN
 1757-9694 
Issue Date
2013
Abstract
We describe a near-infrared-sensitive molecular imaging probe based on hydrogel complexes that can target a stem-like gastric cancer cell marker (CD44, a marker that often correlates with a poor prognosis in patients). Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. NIRSHs demonstrated good water-stability, biocompatibility, and specificity to CD44-expressing stem-like gastric cancer cells. Furthermore, NIR-sensitive in vivo imaging potentials of CD44-targetable NIRSHs for heterotopic/orthotopic xenograft mouse models were investigated.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86740
DOI
10.1039/c3ib20203h
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Institute for Medical Convergence (연의-생공연 메디컬융합연구소)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
구민희(Ku, Min Hee) ; 박은성(Park, Eun Sung) ; 서진석(Suh, Jin Suck) ; 양재문(Yang, Jae Moon) ; 정재호(Cheong, Jae Ho) ; 허용민(Huh, Yong Min)
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Full Text
http://pubs.rsc.org/en/Content/ArticleLanding/2013/IB/c3ib20203h#!divAbstract
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