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TRPV1 Activation in Primary Cortical Neurons Induces Calcium-Dependent Programmed Cell Death

Authors
 Juhyun Song  ;  Jun Hong Lee  ;  Sung Ho Lee  ;  Kyung Ah Park  ;  Won Taek Lee  ;  Jong Eun Lee 
Citation
 EXPERIMENTAL NEUROBIOLOGY, Vol.22(1) : 51-57, 2013 
Journal Title
 EXPERIMENTAL NEUROBIOLOGY 
ISSN
 1226-2560 
Issue Date
2013
Keywords
Ca2+ ; NOS ; apoptosis ; capsaicin ; caspase-3 ; primary neuron
Abstract
Transient receptor potential cation channel, subfamily V, member 1 (TRPV1, also known as vanilloid receptor 1) is a receptor that detects capsaicin, a pungent component of chili peppers, and noxious heat. Although its function in the primary nociceptor as a pain receptor is well established, whether TRPV1 is expressed in the brain is still under debate. In this study, the responses of primary cortical neurons were investigated. Here, we report that 1) capsaicin induces caspase-3-dependent programmed cell death, which coincides with increased production of nitric oxide and peroxynitrite ; that 2) the prolonged capsaicin treatment induces a steady increase in the degree of capase-3 activation, which is prevented by the removal of capsaicin; 3) and that blocking calcium entry and calcium-mediated signaling prevents capsaicin-induced cell death. These results indicate that cortical neurons express TRPV1 whose prolonged activation causes cell death.
Files in This Item:
T201301013.pdf Download
DOI
10.5607/en.2013.22.1.51
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Park, Kyung Ah(박경아)
Song, Ju Hyun(송주현)
Lee, Won Taek(이원택) ORCID logo https://orcid.org/0000-0001-7348-9562
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
Lee, Jun Hong(이준홍)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86693
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