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Neural evidence for emotional involvement in pathological alcohol craving

Authors
 Eun Lee  ;  Jeonghun Ku  ;  Young-Chul Jung  ;  Hyeongrae Lee  ;  Suk Kyoon An  ;  Kyung Ran Kim  ;  Kang-Jun Yoon  ;  Kee Namkoong 
Citation
 ALCOHOL AND ALCOHOLISM, Vol.48(3) : 288-294, 2013 
Journal Title
ALCOHOL AND ALCOHOLISM
ISSN
 0735-0414 
Issue Date
2013
MeSH
Adult ; Alcohol Drinking/psychology ; Alcoholism/psychology* ; Analysis of Variance ; Anesthesia ; Brain/pathology ; Educational Status ; Emotions/physiology* ; Female ; Humans ; Image Processing, Computer-Assisted ; Limbic System/physiopathology ; Magnetic Resonance Imaging ; Male ; Neural Pathways/physiology ; Psychiatric Status Rating Scales
Keywords
Adult ; Alcohol Drinking/psychology ; Alcoholism/psychology* ; Analysis of Variance ; Anesthesia ; Brain/pathology ; Educational Status ; Emotions/physiology* ; Female ; Humans ; Image Processing, Computer-Assisted ; Limbic System/physiopathology ; Magnetic Resonance Imaging ; Male ; Neural Pathways/physiology ; Psychiatric Status Rating Scales
Abstract
AIMS: Reducing craving is a key to success in the treatment of alcohol dependence. The emotion circuit may be involved in pathological craving for alcohol. In this study, we investigated neural correlates of emotional involvement in craving in alcohol dependence.
METHODS: The study included 17 detoxified alcoholic patients and 25 social drinkers. We used functional magnetic resonance imaging to examine brain activation (blood oxygen level-dependent signals) while participants reported craving and emotion in response to visually presented, alcohol-related stimuli and emotional stimuli.
RESULTS: In the craving-rating paradigm, negative emotional stimuli as well as alcohol cues activated craving-related brain regions in alcoholic patients. Activations of the inferior parietal lobule and dorsolateral prefrontal cortex by negative emotional stimuli were negatively correlated with craving; meanwhile limbic activation was positively correlated with craving. For the emotion paradigm, greater limbic activation was evident by alcohol-related stimuli in the alcohol-dependent group.
CONCLUSIONS: Our findings constitute neural evidence for emotional involvement in pathological craving for alcohol, underscoring the importance of emotion management in abstinent alcoholic patients for relapse prevention.
Files in This Item:
T201205566.pdf Download
DOI
10.1093/alcalc/ags130
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Ran(김경란) ORCID logo https://orcid.org/0000-0001-8375-1851
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
Lee, Eun(이은) ORCID logo https://orcid.org/0000-0002-7462-0144
Jung, Young Chul(정영철) ORCID logo https://orcid.org/0000-0002-0578-2510
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86129
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