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Neural evidence for emotional involvement in pathological alcohol craving

DC FieldValueLanguage
dc.contributor.author김경란-
dc.contributor.author남궁기-
dc.contributor.author안석균-
dc.contributor.author이은-
dc.contributor.author정영철-
dc.date.accessioned2014-12-18T08:20:34Z-
dc.date.available2014-12-18T08:20:34Z-
dc.date.issued2013-
dc.identifier.issn0735-0414-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86129-
dc.description.abstractAIMS: Reducing craving is a key to success in the treatment of alcohol dependence. The emotion circuit may be involved in pathological craving for alcohol. In this study, we investigated neural correlates of emotional involvement in craving in alcohol dependence. METHODS: The study included 17 detoxified alcoholic patients and 25 social drinkers. We used functional magnetic resonance imaging to examine brain activation (blood oxygen level-dependent signals) while participants reported craving and emotion in response to visually presented, alcohol-related stimuli and emotional stimuli. RESULTS: In the craving-rating paradigm, negative emotional stimuli as well as alcohol cues activated craving-related brain regions in alcoholic patients. Activations of the inferior parietal lobule and dorsolateral prefrontal cortex by negative emotional stimuli were negatively correlated with craving; meanwhile limbic activation was positively correlated with craving. For the emotion paradigm, greater limbic activation was evident by alcohol-related stimuli in the alcohol-dependent group. CONCLUSIONS: Our findings constitute neural evidence for emotional involvement in pathological craving for alcohol, underscoring the importance of emotion management in abstinent alcoholic patients for relapse prevention.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfALCOHOL AND ALCOHOLISM-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAlcohol Drinking/psychology-
dc.subject.MESHAlcoholism/psychology*-
dc.subject.MESHAnalysis of Variance-
dc.subject.MESHAnesthesia-
dc.subject.MESHBrain/pathology-
dc.subject.MESHEducational Status-
dc.subject.MESHEmotions/physiology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImage Processing, Computer-Assisted-
dc.subject.MESHLimbic System/physiopathology-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHNeural Pathways/physiology-
dc.subject.MESHPsychiatric Status Rating Scales-
dc.titleNeural evidence for emotional involvement in pathological alcohol craving-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학)-
dc.contributor.googleauthorEun Lee-
dc.contributor.googleauthorJeonghun Ku-
dc.contributor.googleauthorYoung-Chul Jung-
dc.contributor.googleauthorHyeongrae Lee-
dc.contributor.googleauthorSuk Kyoon An-
dc.contributor.googleauthorKyung Ran Kim-
dc.contributor.googleauthorKang-Jun Yoon-
dc.contributor.googleauthorKee Namkoong-
dc.identifier.doi10.1093/alcalc/ags130-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03656-
dc.contributor.localIdA00293-
dc.contributor.localIdA01240-
dc.contributor.localIdA02227-
dc.contributor.localIdA03032-
dc.relation.journalcodeJ00059-
dc.identifier.eissn1464-3502-
dc.identifier.pmid23221317-
dc.subject.keywordAdult-
dc.subject.keywordAlcohol Drinking/psychology-
dc.subject.keywordAlcoholism/psychology*-
dc.subject.keywordAnalysis of Variance-
dc.subject.keywordAnesthesia-
dc.subject.keywordBrain/pathology-
dc.subject.keywordEducational Status-
dc.subject.keywordEmotions/physiology*-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordImage Processing, Computer-Assisted-
dc.subject.keywordLimbic System/physiopathology-
dc.subject.keywordMagnetic Resonance Imaging-
dc.subject.keywordMale-
dc.subject.keywordNeural Pathways/physiology-
dc.subject.keywordPsychiatric Status Rating Scales-
dc.contributor.alternativeNameKim, Kyung Ran-
dc.contributor.alternativeNameNamkoong, Kee-
dc.contributor.alternativeNameAn, Suk Kyoon-
dc.contributor.alternativeNameLee, Eun-
dc.contributor.alternativeNameJung, Young Chul-
dc.contributor.affiliatedAuthorJung, Young Chul-
dc.contributor.affiliatedAuthorKim, Kyung Ran-
dc.contributor.affiliatedAuthorNamkoong, Kee-
dc.contributor.affiliatedAuthorAn, Suk Kyoon-
dc.contributor.affiliatedAuthorLee, Eun-
dc.rights.accessRightsfree-
dc.citation.volume48-
dc.citation.number3-
dc.citation.startPage288-
dc.citation.endPage294-
dc.identifier.bibliographicCitationALCOHOL AND ALCOHOLISM, Vol.48(3) : 288-294, 2013-
dc.identifier.rimsid28800-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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