Cited 17 times in
Neural evidence for emotional involvement in pathological alcohol craving
DC Field | Value | Language |
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dc.contributor.author | 김경란 | - |
dc.contributor.author | 남궁기 | - |
dc.contributor.author | 안석균 | - |
dc.contributor.author | 이은 | - |
dc.contributor.author | 정영철 | - |
dc.date.accessioned | 2014-12-18T08:20:34Z | - |
dc.date.available | 2014-12-18T08:20:34Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0735-0414 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86129 | - |
dc.description.abstract | AIMS: Reducing craving is a key to success in the treatment of alcohol dependence. The emotion circuit may be involved in pathological craving for alcohol. In this study, we investigated neural correlates of emotional involvement in craving in alcohol dependence. METHODS: The study included 17 detoxified alcoholic patients and 25 social drinkers. We used functional magnetic resonance imaging to examine brain activation (blood oxygen level-dependent signals) while participants reported craving and emotion in response to visually presented, alcohol-related stimuli and emotional stimuli. RESULTS: In the craving-rating paradigm, negative emotional stimuli as well as alcohol cues activated craving-related brain regions in alcoholic patients. Activations of the inferior parietal lobule and dorsolateral prefrontal cortex by negative emotional stimuli were negatively correlated with craving; meanwhile limbic activation was positively correlated with craving. For the emotion paradigm, greater limbic activation was evident by alcohol-related stimuli in the alcohol-dependent group. CONCLUSIONS: Our findings constitute neural evidence for emotional involvement in pathological craving for alcohol, underscoring the importance of emotion management in abstinent alcoholic patients for relapse prevention. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ALCOHOL AND ALCOHOLISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Alcohol Drinking/psychology | - |
dc.subject.MESH | Alcoholism/psychology* | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Anesthesia | - |
dc.subject.MESH | Brain/pathology | - |
dc.subject.MESH | Educational Status | - |
dc.subject.MESH | Emotions/physiology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Image Processing, Computer-Assisted | - |
dc.subject.MESH | Limbic System/physiopathology | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neural Pathways/physiology | - |
dc.subject.MESH | Psychiatric Status Rating Scales | - |
dc.title | Neural evidence for emotional involvement in pathological alcohol craving | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Eun Lee | - |
dc.contributor.googleauthor | Jeonghun Ku | - |
dc.contributor.googleauthor | Young-Chul Jung | - |
dc.contributor.googleauthor | Hyeongrae Lee | - |
dc.contributor.googleauthor | Suk Kyoon An | - |
dc.contributor.googleauthor | Kyung Ran Kim | - |
dc.contributor.googleauthor | Kang-Jun Yoon | - |
dc.contributor.googleauthor | Kee Namkoong | - |
dc.identifier.doi | 10.1093/alcalc/ags130 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03656 | - |
dc.contributor.localId | A00293 | - |
dc.contributor.localId | A01240 | - |
dc.contributor.localId | A02227 | - |
dc.contributor.localId | A03032 | - |
dc.relation.journalcode | J00059 | - |
dc.identifier.eissn | 1464-3502 | - |
dc.identifier.pmid | 23221317 | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Alcohol Drinking/psychology | - |
dc.subject.keyword | Alcoholism/psychology* | - |
dc.subject.keyword | Analysis of Variance | - |
dc.subject.keyword | Anesthesia | - |
dc.subject.keyword | Brain/pathology | - |
dc.subject.keyword | Educational Status | - |
dc.subject.keyword | Emotions/physiology* | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Image Processing, Computer-Assisted | - |
dc.subject.keyword | Limbic System/physiopathology | - |
dc.subject.keyword | Magnetic Resonance Imaging | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Neural Pathways/physiology | - |
dc.subject.keyword | Psychiatric Status Rating Scales | - |
dc.contributor.alternativeName | Kim, Kyung Ran | - |
dc.contributor.alternativeName | Namkoong, Kee | - |
dc.contributor.alternativeName | An, Suk Kyoon | - |
dc.contributor.alternativeName | Lee, Eun | - |
dc.contributor.alternativeName | Jung, Young Chul | - |
dc.contributor.affiliatedAuthor | Jung, Young Chul | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Ran | - |
dc.contributor.affiliatedAuthor | Namkoong, Kee | - |
dc.contributor.affiliatedAuthor | An, Suk Kyoon | - |
dc.contributor.affiliatedAuthor | Lee, Eun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 48 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 288 | - |
dc.citation.endPage | 294 | - |
dc.identifier.bibliographicCitation | ALCOHOL AND ALCOHOLISM, Vol.48(3) : 288-294, 2013 | - |
dc.identifier.rimsid | 28800 | - |
dc.type.rims | ART | - |
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