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Occlusive membranes for guided regeneration of inflamed tissue defects

Authors
 Woojin Choi  ;  Utkarsh Mangal  ;  Jin-Young Park  ;  Ji-Yeong Kim  ;  Taesuk Jun  ;  Ju Won Jung  ;  Moonhyun Choi  ;  Sungwon Jung  ;  Milae Lee  ;  Ji-Yeong Na  ;  Du Yeol Ryu  ;  Jin Man Kim  ;  Jae-Sung Kwon  ;  Won-Gun Koh  ;  Sangmin Lee  ;  Patrick T J Hwang  ;  Kee-Joon Lee  ;  Ui-Won Jung  ;  Jae-Kook Cha  ;  Sung-Hwan Choi  ;  Jinkee Hong 
Citation
 NATURE COMMUNICATIONS, Vol.14(1) : 7687, 2023-11 
Journal Title
NATURE COMMUNICATIONS
Issue Date
2023-11
MeSH
Alveolar Bone Loss* ; Bone Regeneration / physiology ; Gingiva ; Guided Tissue Regeneration, Periodontal ; Humans ; Membranes, Artificial ; Periodontitis* ; Wound Healing / physiology
Abstract
Guided bone regeneration aided by the application of occlusive membranes is a promising therapy for diverse inflammatory periodontal diseases. Symbiosis, homeostasis between the host microbiome and cells, occurs in the oral environment under normal, but not pathologic, conditions. Here, we develop a symbiotically integrating occlusive membrane by mimicking the tooth enamel growth or multiple nucleation biomineralization processes. We perform human saliva and in vivo canine experiments to confirm that the symbiotically integrating occlusive membrane induces a symbiotic healing environment. Moreover, we show that the membrane exhibits tractability and enzymatic stability, maintaining the healing space during the entire guided bone regeneration therapy period. We apply the symbiotically integrating occlusive membrane to treat inflammatory-challenged cases in vivo, namely, the open and closed healing of canine premolars with severe periodontitis. We find that the membrane promotes symbiosis, prevents negative inflammatory responses, and improves cellular integration. Finally, we show that guided bone regeneration therapy with the symbiotically integrating occlusive membrane achieves fast healing of gingival soft tissue and alveolar bone.
Files in This Item:
T202306995.pdf Download
DOI
10.1038/s41467-023-43428-3
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Jae-Sung(권재성) ORCID logo https://orcid.org/0000-0001-9803-7730
Mangal, Utkarsh(만갈웃커시)
Park, Jin Young(박진영)
Lee, Kee Joon(이기준) ORCID logo https://orcid.org/0000-0002-0782-3128
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cha, Jae Kook(차재국) ORCID logo https://orcid.org/0000-0001-6817-9834
Choi, Sung Hwan(최성환) ORCID logo https://orcid.org/0000-0002-1150-0268
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197548
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