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Cited 2 times in

Occlusive membranes for guided regeneration of inflamed tissue defects

DC Field Value Language
dc.contributor.author권재성-
dc.contributor.author이기준-
dc.contributor.author정의원-
dc.contributor.author차재국-
dc.contributor.author최성환-
dc.contributor.author박진영-
dc.contributor.author만갈웃커시-
dc.date.accessioned2024-01-03T01:25:05Z-
dc.date.available2024-01-03T01:25:05Z-
dc.date.issued2023-11-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/197548-
dc.description.abstractGuided bone regeneration aided by the application of occlusive membranes is a promising therapy for diverse inflammatory periodontal diseases. Symbiosis, homeostasis between the host microbiome and cells, occurs in the oral environment under normal, but not pathologic, conditions. Here, we develop a symbiotically integrating occlusive membrane by mimicking the tooth enamel growth or multiple nucleation biomineralization processes. We perform human saliva and in vivo canine experiments to confirm that the symbiotically integrating occlusive membrane induces a symbiotic healing environment. Moreover, we show that the membrane exhibits tractability and enzymatic stability, maintaining the healing space during the entire guided bone regeneration therapy period. We apply the symbiotically integrating occlusive membrane to treat inflammatory-challenged cases in vivo, namely, the open and closed healing of canine premolars with severe periodontitis. We find that the membrane promotes symbiosis, prevents negative inflammatory responses, and improves cellular integration. Finally, we show that guided bone regeneration therapy with the symbiotically integrating occlusive membrane achieves fast healing of gingival soft tissue and alveolar bone.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Pub. Group-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAlveolar Bone Loss*-
dc.subject.MESHBone Regeneration / physiology-
dc.subject.MESHGingiva-
dc.subject.MESHGuided Tissue Regeneration, Periodontal-
dc.subject.MESHHumans-
dc.subject.MESHMembranes, Artificial-
dc.subject.MESHPeriodontitis*-
dc.subject.MESHWound Healing / physiology-
dc.titleOcclusive membranes for guided regeneration of inflamed tissue defects-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실)-
dc.contributor.googleauthorWoojin Choi-
dc.contributor.googleauthorUtkarsh Mangal-
dc.contributor.googleauthorJin-Young Park-
dc.contributor.googleauthorJi-Yeong Kim-
dc.contributor.googleauthorTaesuk Jun-
dc.contributor.googleauthorJu Won Jung-
dc.contributor.googleauthorMoonhyun Choi-
dc.contributor.googleauthorSungwon Jung-
dc.contributor.googleauthorMilae Lee-
dc.contributor.googleauthorJi-Yeong Na-
dc.contributor.googleauthorDu Yeol Ryu-
dc.contributor.googleauthorJin Man Kim-
dc.contributor.googleauthorJae-Sung Kwon-
dc.contributor.googleauthorWon-Gun Koh-
dc.contributor.googleauthorSangmin Lee-
dc.contributor.googleauthorPatrick T J Hwang-
dc.contributor.googleauthorKee-Joon Lee-
dc.contributor.googleauthorUi-Won Jung-
dc.contributor.googleauthorJae-Kook Cha-
dc.contributor.googleauthorSung-Hwan Choi-
dc.contributor.googleauthorJinkee Hong-
dc.identifier.doi10.1038/s41467-023-43428-3-
dc.contributor.localIdA00247-
dc.contributor.localIdA02698-
dc.contributor.localIdA03692-
dc.contributor.localIdA04004-
dc.contributor.localIdA04083-
dc.relation.journalcodeJ02293-
dc.identifier.eissn2041-1723-
dc.identifier.pmid38001080-
dc.contributor.alternativeNameKwon, Jae-Sung-
dc.contributor.affiliatedAuthor권재성-
dc.contributor.affiliatedAuthor이기준-
dc.contributor.affiliatedAuthor정의원-
dc.contributor.affiliatedAuthor차재국-
dc.contributor.affiliatedAuthor최성환-
dc.citation.volume14-
dc.citation.number1-
dc.citation.startPage7687-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, Vol.14(1) : 7687, 2023-11-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

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