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Improving Bone Formation by Guided Bone Regeneration Using a Collagen Membrane with rhBMP-2: A Novel Concept

Authors
 Narae Jung  ;  Jaehan Park  ;  Sang-Hyun Park  ;  Seunghan Oh  ;  Sungtae Kim  ;  Sung-Won Cho  ;  Jong-Eun Kim  ;  Hong Seok Moon  ;  Young-Bum Park 
Citation
 JOURNAL OF FUNCTIONAL BIOMATERIALS, Vol.14(3) : 170, 2023-03 
Journal Title
 JOURNAL OF FUNCTIONAL BIOMATERIALS 
Issue Date
2023-03
Keywords
biphasic calcium phosphate ; bone formation ; collagen membrane ; guided bone regeneration ; rhBMP-2
Abstract
We examined whether recombinant human bone morphogenetic protein-2 (rhBMP-2) when applied to collagen membranes, would reinforce them during guided bone regeneration. Four critical cranial bone defects were created and treated in 30 New Zealand white rabbits, including a control group, critical defect only; group 1, collagen membrane only; group 2, biphasic calcium phosphate (BCP) only; group 3, collagen membrane + BCP; group 4, collagen membrane with rhBMP-2 (1.0 mg/mL); group 5, collagen membrane with rhBMP-2 (0.5 mg/mL); group 6, collagen membrane with rhBMP-2 (1.0 mg/mL) + BCP; and group 7, collagen membrane with rhBMP-2 (0.5 mg/mL) + BCP. After a 2-, 4-, or 8-week healing period, the animals were sacrificed. The combination of collagen membranes with rhBMP-2 and BCP yielded significantly higher bone formation rates compared to the other groups (control group and groups 1–5 < groups 6 and 7; p < 0.05). A 2-week healing period yielded significantly lower bone formation than that at 4 and 8 weeks (2 < 4 = 8 weeks; p < 0.05). This study proposes a novel GBR concept in which rhBMP-2 is applied to collagen membranes outside instead of inside the grafted area, thereby inducing quantitatively and qualitatively enhanced bone regeneration in critical bone defects. © 2023 by the authors.
Files in This Item:
T202304319.pdf Download
DOI
10.3390/jfb14030170
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Eun(김종은) ORCID logo https://orcid.org/0000-0002-7834-2524
Moon, Hong Seok(문홍석) ORCID logo https://orcid.org/0000-0001-8118-8145
Park, Young Bum(박영범)
Park, Jae Han(박재한)
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/196008
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