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Improving Bone Formation by Guided Bone Regeneration Using a Collagen Membrane with rhBMP-2: A Novel Concept
DC Field | Value | Language |
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dc.contributor.author | 김종은 | - |
dc.contributor.author | 문홍석 | - |
dc.contributor.author | 박영범 | - |
dc.contributor.author | 박재한 | - |
dc.contributor.author | 조성원 | - |
dc.date.accessioned | 2023-08-09T06:56:47Z | - |
dc.date.available | 2023-08-09T06:56:47Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196008 | - |
dc.description.abstract | We examined whether recombinant human bone morphogenetic protein-2 (rhBMP-2) when applied to collagen membranes, would reinforce them during guided bone regeneration. Four critical cranial bone defects were created and treated in 30 New Zealand white rabbits, including a control group, critical defect only; group 1, collagen membrane only; group 2, biphasic calcium phosphate (BCP) only; group 3, collagen membrane + BCP; group 4, collagen membrane with rhBMP-2 (1.0 mg/mL); group 5, collagen membrane with rhBMP-2 (0.5 mg/mL); group 6, collagen membrane with rhBMP-2 (1.0 mg/mL) + BCP; and group 7, collagen membrane with rhBMP-2 (0.5 mg/mL) + BCP. After a 2-, 4-, or 8-week healing period, the animals were sacrificed. The combination of collagen membranes with rhBMP-2 and BCP yielded significantly higher bone formation rates compared to the other groups (control group and groups 1–5 < groups 6 and 7; p < 0.05). A 2-week healing period yielded significantly lower bone formation than that at 4 and 8 weeks (2 < 4 = 8 weeks; p < 0.05). This study proposes a novel GBR concept in which rhBMP-2 is applied to collagen membranes outside instead of inside the grafted area, thereby inducing quantitatively and qualitatively enhanced bone regeneration in critical bone defects. © 2023 by the authors. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF FUNCTIONAL BIOMATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Improving Bone Formation by Guided Bone Regeneration Using a Collagen Membrane with rhBMP-2: A Novel Concept | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Prosthodontics (보철과학교실) | - |
dc.contributor.googleauthor | Narae Jung | - |
dc.contributor.googleauthor | Jaehan Park | - |
dc.contributor.googleauthor | Sang-Hyun Park | - |
dc.contributor.googleauthor | Seunghan Oh | - |
dc.contributor.googleauthor | Sungtae Kim | - |
dc.contributor.googleauthor | Sung-Won Cho | - |
dc.contributor.googleauthor | Jong-Eun Kim | - |
dc.contributor.googleauthor | Hong Seok Moon | - |
dc.contributor.googleauthor | Young-Bum Park | - |
dc.identifier.doi | 10.3390/jfb14030170 | - |
dc.contributor.localId | A00927 | - |
dc.contributor.localId | A01395 | - |
dc.contributor.localId | A01567 | - |
dc.contributor.localId | A06341 | - |
dc.contributor.localId | A03837 | - |
dc.relation.journalcode | J04438 | - |
dc.identifier.pmid | 36976094 | - |
dc.subject.keyword | biphasic calcium phosphate | - |
dc.subject.keyword | bone formation | - |
dc.subject.keyword | collagen membrane | - |
dc.subject.keyword | guided bone regeneration | - |
dc.subject.keyword | rhBMP-2 | - |
dc.contributor.alternativeName | Kim, Jong Eun | - |
dc.contributor.affiliatedAuthor | 김종은 | - |
dc.contributor.affiliatedAuthor | 문홍석 | - |
dc.contributor.affiliatedAuthor | 박영범 | - |
dc.contributor.affiliatedAuthor | 박재한 | - |
dc.contributor.affiliatedAuthor | 조성원 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 170 | - |
dc.identifier.bibliographicCitation | JOURNAL OF FUNCTIONAL BIOMATERIALS, Vol.14(3) : 170, 2023-03 | - |
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