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Altered intrinsic brain activity after chemotherapy in patients with gastric cancer: A preliminary study

Authors
 Hyun Gi Kim  ;  Na-Young Shin  ;  Yunjin Bak  ;  Kyung Ran Kim  ;  Young-Chul Jung  ;  Kyunghwa Han  ;  Seung-Koo Lee  ;  Soo Mee Lim 
Citation
 EUROPEAN RADIOLOGY, Vol.27(7) : 2679-2688, 2017-07 
Journal Title
EUROPEAN RADIOLOGY
ISSN
 0938-7994 
Issue Date
2017-07
MeSH
Adult ; Analysis of Variance ; Antineoplastic Agents / adverse effects* ; Attention / drug effects ; Attention / physiology ; Brain / drug effects ; Brain / physiopathology* ; Case-Control Studies ; Cognition / drug effects ; Cognition / physiology ; Executive Function / drug effects ; Executive Function / physiology ; Frontal Lobe / physiopathology ; Humans ; Magnetic Resonance Imaging / methods ; Male ; Middle Aged ; Neuropsychological Tests ; Prospective Studies ; Stomach Neoplasms / drug therapy* ; Stomach Neoplasms / physiopathology ; Verbal Learning / drug effects ; Verbal Learning / physiology
Keywords
Brain ; Cancer chemotherapy agents ; Cognitive function ; Functional magnetic resonance imaging ; Gastric cancer.
Abstract
Objectives: To characterize the pattern of altered intrinsic brain activity in gastric cancer patients after chemotherapy (CTx).

Methods: Patients before and after CTx (n = 14) and control subjects (n = 11) underwent resting-state functional MRI (rsfMRI) at baseline and 3 months after CTx. Regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF) were calculated and compared between the groups using the two-sample t test. Correlation analysis was also performed between rsfMRI values (i.e., ReHo, ALFF, and fALFF) and neuropsychological test results.

Results: Patients showed poor performance in verbal memory and executive function and decreased rsfMRI values in the frontal areas even before CTx and showed decreased attention/working memory and executive function after CTx compared to the control subjects. In direct comparison of values before and after CTx, there were no significant differences in neuropsychological test scores, but decreased rsfMRI values were observed at the frontal lobes and right cerebellar region. Among rsfMRI values, lower ALFF in the left inferior frontal gyrus was significantly associated with poor performance of the executive function test.

Conclusions: We observed decreased attention/working memory and executive function that corresponded to the decline of frontal region activation in gastric cancer patients who underwent CTx.

Key points: • Intrinsic brain activity of gastric cancer patients after chemotherapy was described. • Brain activity and neuropsychological test results were correlated. • Working memory and executive function decreased after chemotherapy. • Decreased cognitive function corresponded to decreased activation of the frontal region.
Full Text
https://link.springer.com/article/10.1007/s00330-016-4578-x
DOI
10.1007/s00330-016-4578-x
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Ran(김경란) ORCID logo https://orcid.org/0000-0001-8375-1851
Shin, Na Young(신나영)
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Jung, Young Chul(정영철) ORCID logo https://orcid.org/0000-0002-0578-2510
Han, Kyung Hwa(한경화)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195692
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