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Altered intrinsic brain activity after chemotherapy in patients with gastric cancer: A preliminary study

DC Field Value Language
dc.contributor.author신나영-
dc.contributor.author정영철-
dc.contributor.author이승구-
dc.contributor.author한경화-
dc.contributor.author김경란-
dc.date.accessioned2023-08-09T02:37:38Z-
dc.date.available2023-08-09T02:37:38Z-
dc.date.issued2017-07-
dc.identifier.issn0938-7994-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/195692-
dc.description.abstractObjectives: To characterize the pattern of altered intrinsic brain activity in gastric cancer patients after chemotherapy (CTx). Methods: Patients before and after CTx (n = 14) and control subjects (n = 11) underwent resting-state functional MRI (rsfMRI) at baseline and 3 months after CTx. Regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF) were calculated and compared between the groups using the two-sample t test. Correlation analysis was also performed between rsfMRI values (i.e., ReHo, ALFF, and fALFF) and neuropsychological test results. Results: Patients showed poor performance in verbal memory and executive function and decreased rsfMRI values in the frontal areas even before CTx and showed decreased attention/working memory and executive function after CTx compared to the control subjects. In direct comparison of values before and after CTx, there were no significant differences in neuropsychological test scores, but decreased rsfMRI values were observed at the frontal lobes and right cerebellar region. Among rsfMRI values, lower ALFF in the left inferior frontal gyrus was significantly associated with poor performance of the executive function test. Conclusions: We observed decreased attention/working memory and executive function that corresponded to the decline of frontal region activation in gastric cancer patients who underwent CTx. Key points: • Intrinsic brain activity of gastric cancer patients after chemotherapy was described. • Brain activity and neuropsychological test results were correlated. • Working memory and executive function decreased after chemotherapy. • Decreased cognitive function corresponded to decreased activation of the frontal region.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer International-
dc.relation.isPartOfEUROPEAN RADIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAnalysis of Variance-
dc.subject.MESHAntineoplastic Agents / adverse effects*-
dc.subject.MESHAttention / drug effects-
dc.subject.MESHAttention / physiology-
dc.subject.MESHBrain / drug effects-
dc.subject.MESHBrain / physiopathology*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCognition / drug effects-
dc.subject.MESHCognition / physiology-
dc.subject.MESHExecutive Function / drug effects-
dc.subject.MESHExecutive Function / physiology-
dc.subject.MESHFrontal Lobe / physiopathology-
dc.subject.MESHHumans-
dc.subject.MESHMagnetic Resonance Imaging / methods-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeuropsychological Tests-
dc.subject.MESHProspective Studies-
dc.subject.MESHStomach Neoplasms / drug therapy*-
dc.subject.MESHStomach Neoplasms / physiopathology-
dc.subject.MESHVerbal Learning / drug effects-
dc.subject.MESHVerbal Learning / physiology-
dc.titleAltered intrinsic brain activity after chemotherapy in patients with gastric cancer: A preliminary study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorHyun Gi Kim-
dc.contributor.googleauthorNa-Young Shin-
dc.contributor.googleauthorYunjin Bak-
dc.contributor.googleauthorKyung Ran Kim-
dc.contributor.googleauthorYoung-Chul Jung-
dc.contributor.googleauthorKyunghwa Han-
dc.contributor.googleauthorSeung-Koo Lee-
dc.contributor.googleauthorSoo Mee Lim-
dc.identifier.doi10.1007/s00330-016-4578-x-
dc.contributor.localIdA02089-
dc.contributor.localIdA03656-
dc.contributor.localIdA02912-
dc.contributor.localIdA04267-
dc.relation.journalcodeJ00851-
dc.identifier.eissn1432-1084-
dc.identifier.pmid27878584-
dc.identifier.urlhttps://link.springer.com/article/10.1007/s00330-016-4578-x-
dc.subject.keywordBrain-
dc.subject.keywordCancer chemotherapy agents-
dc.subject.keywordCognitive function-
dc.subject.keywordFunctional magnetic resonance imaging-
dc.subject.keywordGastric cancer.-
dc.contributor.alternativeNameShin, Na Young-
dc.contributor.affiliatedAuthor신나영-
dc.contributor.affiliatedAuthor정영철-
dc.contributor.affiliatedAuthor이승구-
dc.contributor.affiliatedAuthor한경화-
dc.citation.volume27-
dc.citation.number7-
dc.citation.startPage2679-
dc.citation.endPage2688-
dc.identifier.bibliographicCitationEUROPEAN RADIOLOGY, Vol.27(7) : 2679-2688, 2017-07-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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