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Role of Enlarged Perivascular Space in the Temporal Lobe in Cerebral Amyloidosis

Authors
 Han Kyu Na  ;  Han-Kyeol Kim  ;  Hye Sun Lee  ;  Mina Park  ;  Jae Hoon Lee  ;  Young Hoon Ryu  ;  Hanna Cho  ;  Chul Hyoung Lyoo 
Citation
 ANNALS OF NEUROLOGY, Vol.93(5) : 965-978, 2023-05 
Journal Title
ANNALS OF NEUROLOGY
ISSN
 0364-5134 
Issue Date
2023-05
MeSH
Amyloidosis* / diagnostic imaging ; Cognitive Dysfunction* / diagnostic imaging ; Cognitive Dysfunction* / etiology ; Humans ; Magnetic Resonance Imaging ; Positron-Emission Tomography ; Temporal Lobe / diagnostic imaging
Abstract
Objective: Although growing evidence suggests that perivascular space (PVS) serves as a clearance route for amyloid and tau, the association between enlarged PVS (EPVS) and Alzheimer disease is highly inconsistent across studies. As the conventional visual rating systems for EPVS were insufficient to predict amyloid/tau/neurodegeneration (A/T/N) status, we developed a new rating scale for EPVS located in the temporal lobe (T-EPVS).

Methods: EPVS located in the basal ganglia (BG-EPVS), centrum semiovale (CS-EPVS), and T-EPVS was visually rated in 272 individuals (healthy controls, n = 96; mild cognitive impairment, n = 106; dementia, n = 70) who underwent structural magnetic resonance imaging (MRI) and dual positron emission tomography scans (18 F-flortaucipir and 18 F-florbetaben). T-EPVS and BG-EPVS were defined as high degree when the counts in any hemisphere were >10, and the CS-EPVS cutoff was >20. Logistic regression models were constructed to investigate whether the regional EPVS burden was predictive of A/T/N status. The derived models were externally validated in a temporal validation cohort (n = 195) that underwent MRI studies using a different scanner.

Results: Compared with those with low-degree T-EPVS (23/136, 16.9%), individuals with high-degree T-EPVS/CS-EPVS but low-degree BG-EPVS were more likely to exhibit amyloid positivity (46/56, 82.1%). High-degree T-EPVS burden (odds ratio [OR] = 7.251, 95% confidence interval [CI] = 3.296-15.952) and low-degree BG-EPVS (OR = 0.241, 95% CI = 0.109-0.530) were predictive of amyloid positivity. Although high-degree T-EPVS was associated with tau positivity, the association was no longer significant after adjusting for amyloid and neurodegeneration status.

Interpretation: Investigating the burden and topographic distribution of EPVS including T-EPVS may be useful for predicting amyloid status, indicating that impaired perivascular drainage may contribute to cerebral amyloidosis. ANN NEUROL 2023;93:965-978.

© 2029 American Neurological Association.
Full Text
https://onlinelibrary.wiley.com/doi/10.1002/ana.26601
DOI
10.1002/ana.26601
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Han kyeol(김한결) ORCID logo https://orcid.org/0000-0002-7650-6708
Na, Han Kyu(나한규)
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Park, Mina(박미나) ORCID logo https://orcid.org/0000-0002-2005-7560
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0002-9898-9886
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195543
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