Cited 0 times in

Associations of Particulate Matter Exposures With Brain Gray Matter Thickness and White Matter Hyperintensities: Effect Modification by Low-Grade Chronic Inflammation

Authors
 Jaelim Cho  ;  Heeseon Jang  ;  Young Noh  ;  Seung-Koo Lee  ;  Sang-Baek Koh  ;  Sun-Young Kim  ;  Changsoo Kim 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.38(16) : e159, 2023-04 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2023-04
MeSH
Adult ; Air Pollutants* ; Brain ; Cross-Sectional Studies ; Environmental Exposure ; Gray Matter ; Humans ; Inflammation ; Male ; Particulate Matter / analysis ; Prospective Studies ; White Matter* / chemistry
Keywords
Air Pollution ; Brain Cortical Thickness ; Chronic Inflammation ; Neuroimaging ; White Matter Hyperintensity
Abstract
Background: Numerous studies have shown the effect of particulate matter exposure on brain imaging markers. However, little evidence exists about whether the effect differs by the level of low-grade chronic systemic inflammation. We investigated whether the level of c-reactive protein (CRP, a marker of systemic inflammation) modifies the associations of particulate matter exposures with brain cortical gray matter thickness and white matter hyperintensities (WMH).

Methods: We conducted a cross-sectional study of baseline data from a prospective cohort study including adults with no dementia or stroke. Long-term concentrations of particulate matter ≤ 10 µm in diameter (PM10) and ≤ 2.5 µm (PM2.5) at each participant’s home address were estimated. Global cortical thickness (n = 874) and WMH volumes (n = 397) were estimated from brain magnetic resonance images. We built linear and logistic regression models for cortical thickness and WMH volumes (higher versus lower than median), respectively. Significance of difference in the association between the CRP group (higher versus lower than median) was expressed as P for interaction.

Results: Particulate matter exposures were significantly associated with a reduced global cortical thickness only in the higher CRP group among men (P for interaction = 0.015 for PM10 and 0.006 for PM2.5). A 10 μg/m3 increase in PM10 was associated with the higher volumes of total WMH (odds ratio, 1.78; 95% confidence interval, 1.07–2.97) and periventricular WMH (2.00; 1.20–3.33). A 1 μg/m3 increase in PM2.5 was associated with the higher volume of periventricular WMH (odds ratio, 1.66; 95% confidence interval, 1.08–2.56). These associations did not significantly differ by the level of high sensitivity CRP.

Conclusion: Particulate matter exposures were associated with a reduced global cortical thickness in men with a high level of chronic inflammation. Men with a high level of chronic inflammation may be susceptible to cortical atrophy attributable to particulate matter exposures.
Files in This Item:
T202302918.pdf Download
DOI
10.3346/jkms.2023.38.e159
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Jang, Heeseon(장희선) ORCID logo https://orcid.org/0000-0002-9737-7220
Cho, Jae Lim(조재림)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195309
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links