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Associations of Particulate Matter Exposures With Brain Gray Matter Thickness and White Matter Hyperintensities: Effect Modification by Low-Grade Chronic Inflammation

DC Field Value Language
dc.contributor.author김창수-
dc.contributor.author이승구-
dc.contributor.author조재림-
dc.contributor.author장희선-
dc.date.accessioned2023-07-12T02:26:38Z-
dc.date.available2023-07-12T02:26:38Z-
dc.date.issued2023-04-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/195309-
dc.description.abstractBackground: Numerous studies have shown the effect of particulate matter exposure on brain imaging markers. However, little evidence exists about whether the effect differs by the level of low-grade chronic systemic inflammation. We investigated whether the level of c-reactive protein (CRP, a marker of systemic inflammation) modifies the associations of particulate matter exposures with brain cortical gray matter thickness and white matter hyperintensities (WMH). Methods: We conducted a cross-sectional study of baseline data from a prospective cohort study including adults with no dementia or stroke. Long-term concentrations of particulate matter ≤ 10 µm in diameter (PM10) and ≤ 2.5 µm (PM2.5) at each participant’s home address were estimated. Global cortical thickness (n = 874) and WMH volumes (n = 397) were estimated from brain magnetic resonance images. We built linear and logistic regression models for cortical thickness and WMH volumes (higher versus lower than median), respectively. Significance of difference in the association between the CRP group (higher versus lower than median) was expressed as P for interaction. Results: Particulate matter exposures were significantly associated with a reduced global cortical thickness only in the higher CRP group among men (P for interaction = 0.015 for PM10 and 0.006 for PM2.5). A 10 μg/m3 increase in PM10 was associated with the higher volumes of total WMH (odds ratio, 1.78; 95% confidence interval, 1.07–2.97) and periventricular WMH (2.00; 1.20–3.33). A 1 μg/m3 increase in PM2.5 was associated with the higher volume of periventricular WMH (odds ratio, 1.66; 95% confidence interval, 1.08–2.56). These associations did not significantly differ by the level of high sensitivity CRP. Conclusion: Particulate matter exposures were associated with a reduced global cortical thickness in men with a high level of chronic inflammation. Men with a high level of chronic inflammation may be susceptible to cortical atrophy attributable to particulate matter exposures.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisher대한의학회(The Korean Academy of Medical Sciences)-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAir Pollutants*-
dc.subject.MESHBrain-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHEnvironmental Exposure-
dc.subject.MESHGray Matter-
dc.subject.MESHHumans-
dc.subject.MESHInflammation-
dc.subject.MESHMale-
dc.subject.MESHParticulate Matter / analysis-
dc.subject.MESHProspective Studies-
dc.subject.MESHWhite Matter* / chemistry-
dc.titleAssociations of Particulate Matter Exposures With Brain Gray Matter Thickness and White Matter Hyperintensities: Effect Modification by Low-Grade Chronic Inflammation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine (예방의학교실)-
dc.contributor.googleauthorJaelim Cho-
dc.contributor.googleauthorHeeseon Jang-
dc.contributor.googleauthorYoung Noh-
dc.contributor.googleauthorSeung-Koo Lee-
dc.contributor.googleauthorSang-Baek Koh-
dc.contributor.googleauthorSun-Young Kim-
dc.contributor.googleauthorChangsoo Kim-
dc.identifier.doi10.3346/jkms.2023.38.e159-
dc.contributor.localIdA01042-
dc.contributor.localIdA02912-
dc.contributor.localIdA03895-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid37096314-
dc.subject.keywordAir Pollution-
dc.subject.keywordBrain Cortical Thickness-
dc.subject.keywordChronic Inflammation-
dc.subject.keywordNeuroimaging-
dc.subject.keywordWhite Matter Hyperintensity-
dc.contributor.alternativeNameKim, Chang Soo-
dc.contributor.affiliatedAuthor김창수-
dc.contributor.affiliatedAuthor이승구-
dc.contributor.affiliatedAuthor조재림-
dc.citation.volume38-
dc.citation.number16-
dc.citation.startPagee159-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.38(16) : e159, 2023-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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