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백서의 임의 피부 피판 모델에서 국소 주입한 PDRN 약물의 피판 보호 효과

Other Titles
 Protective Effect of Locally Injected Polydeoxyribonucleotide in Ischemic Murine Random Skin Flaps 
 Jiye Kim  ;  Jaemoon Yang  ;  Minhee Ku  ;  Ji Yong Lee  ;  Eun Chang Choi  ;  Ji-Hoon Kim 
 Korean Journal of Otorhinolaryngology-Head and Neck Surgery, Vol.66(2) : 106-112, 2023-02 
Journal Title
Korean Journal of Otorhinolaryngology-Head and Neck Surgery
Issue Date
Laser speckle contrast imaging ; Necrosis ; Polydeoxyribonucleotide ; Surgical flaps
Background and Objectives
This study aimed to investigate the protective effect of polydeoxyribonucleotide (PDRN) against skin flap necrosis in a murine skin flap model.Materials and Method Twenty mice with rectangular skin flaps on the dorsum were randomly divided into the PDRN (n=10) and pentobarbital sodium (PBS) (n=10) injection groups. PDRN (8 mg/kg) was subdermally injected at 12 different points immediately after the operation. After 7 days, the flap perfusions were evaluated using a laser speckle contrast imaging (LSCI) system, and specimens were collected for immunohistochemistry analysis.
The percentage of survival area relative to the total flap area was significantly higher in the PDRN group (60.87%±7.63%) than in the PBS group (45.23%±10.72%) (p<0.05). The mean LSCI perfusion signal of the distal part of the skin flap in the PBS group was 0.57±0.12, and that in the PDRN group was 0.74±0.13 (p<0.05). The PDRN group had a significantly lower interleukin 1 beta expression than the PBS group and higher vascular endothelial growth factor α expression than the PBS group (p<0.05).
These findings suggest that subdermally injected PDRN is more effective in enhancing flap survival during necrosis.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Koh, Yoon Woo(고윤우)
Ku, Min Hee(구민희) ORCID logo https://orcid.org/0000-0002-1674-1474
Sim, Nam Suk(심남석)
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Choi, Eun Chang(최은창)
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