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백서의 임의 피부 피판 모델에서 국소 주입한 PDRN 약물의 피판 보호 효과

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dc.contributor.author고윤우-
dc.contributor.author구민희-
dc.contributor.author심남석-
dc.contributor.author양재문-
dc.contributor.author최은창-
dc.contributor.author심남석-
dc.contributor.author김지훈-
dc.date.accessioned2023-03-27T02:57:53Z-
dc.date.available2023-03-27T02:57:53Z-
dc.date.issued2023-02-
dc.identifier.issn2092-5859-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/193751-
dc.description.abstractBackground and Objectives This study aimed to investigate the protective effect of polydeoxyribonucleotide (PDRN) against skin flap necrosis in a murine skin flap model.Materials and Method Twenty mice with rectangular skin flaps on the dorsum were randomly divided into the PDRN (n=10) and pentobarbital sodium (PBS) (n=10) injection groups. PDRN (8 mg/kg) was subdermally injected at 12 different points immediately after the operation. After 7 days, the flap perfusions were evaluated using a laser speckle contrast imaging (LSCI) system, and specimens were collected for immunohistochemistry analysis. Results The percentage of survival area relative to the total flap area was significantly higher in the PDRN group (60.87%±7.63%) than in the PBS group (45.23%±10.72%) (p<0.05). The mean LSCI perfusion signal of the distal part of the skin flap in the PBS group was 0.57±0.12, and that in the PDRN group was 0.74±0.13 (p<0.05). The PDRN group had a significantly lower interleukin 1 beta expression than the PBS group and higher vascular endothelial growth factor α expression than the PBS group (p<0.05). Conclusion These findings suggest that subdermally injected PDRN is more effective in enhancing flap survival during necrosis.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageKorean-
dc.publisher대한이비인후과학회-
dc.relation.isPartOfKorean Journal of Otorhinolaryngology-Head and Neck Surgery-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title백서의 임의 피부 피판 모델에서 국소 주입한 PDRN 약물의 피판 보호 효과-
dc.title.alternativeProtective Effect of Locally Injected Polydeoxyribonucleotide in Ischemic Murine Random Skin Flaps-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학교실)-
dc.contributor.googleauthorJiye Kim-
dc.contributor.googleauthorJaemoon Yang-
dc.contributor.googleauthorMinhee Ku-
dc.contributor.googleauthorJi Yong Lee-
dc.contributor.googleauthorEun Chang Choi-
dc.contributor.googleauthorJi-Hoon Kim-
dc.identifier.doi10.3342/kjorl-hns.2022.00696-
dc.contributor.localIdA00133-
dc.contributor.localIdA00191-
dc.contributor.localIdA06297-
dc.contributor.localIdA02315-
dc.contributor.localIdA04161-
dc.relation.journalcodeJ02089-
dc.identifier.eissn2092-6529-
dc.subject.keywordLaser speckle contrast imaging-
dc.subject.keywordNecrosis-
dc.subject.keywordPolydeoxyribonucleotide-
dc.subject.keywordSurgical flaps-
dc.contributor.alternativeNameKoh, Yoon Woo-
dc.contributor.affiliatedAuthor고윤우-
dc.contributor.affiliatedAuthor구민희-
dc.contributor.affiliatedAuthor심남석-
dc.contributor.affiliatedAuthor양재문-
dc.contributor.affiliatedAuthor최은창-
dc.citation.volume66-
dc.citation.number2-
dc.citation.startPage106-
dc.citation.endPage112-
dc.identifier.bibliographicCitationKorean Journal of Otorhinolaryngology-Head and Neck Surgery, Vol.66(2) : 106-112, 2023-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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