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Cutoff Points of Waist Circumference for Predicting Incident Non-Alcoholic Fatty Liver Disease in Middle-Aged and Older Korean Adults

 Jun-Hyuk Lee  ;  Soyoung Jeon  ;  Hye Sun Lee  ;  Yu-Jin Kwon 
 NUTRIENTS, Vol.14(14) : 2994, 2022-07 
Journal Title
Issue Date
Adult ; Aged ; Body Mass Index ; Female ; Humans ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease* / diagnosis ; Non-alcoholic Fatty Liver Disease* / epidemiology ; Prospective Studies ; Republic of Korea / epidemiology ; Risk Factors ; Waist Circumference
abdominal obesity ; body mass index ; non-alcoholic fatty liver disease ; waist circumference
This study aimed to determine the optimal cutoff value of waist circumference (WC) for predicting incident NAFLD. In this community-based prospective cohort study, we analyzed data from 5400 participants without NAFLD at baseline aged 40-69 years. NAFLD was defined as a NAFLD-liver fat score >-0.640. A Cox proportional hazards regression model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for an association between body composition and NAFLD incidence. The predictive power of each body composition indicator was assessed by Harrell's concordance index for Cox models. During a mean follow-up period of 12 years, there were 2366 new-onset NAFLD events. Compared with men with WC < 81 cm, the adjusted HR (95% CI) for incident NAFLD in those with WC ≥ 81 cm was 2.44 (2.23-2.67). Compared with women with WC < 78.5 cm, the adjusted HR (95% CI) for incident NAFLD in those with WC ≥ 78.5 cm was 2.54 (2.25-2.87). WC was the most significant risk factor for predicting incident NAFLD among body composition indicators in middle-aged and older Korean adults. The optimal WC cutoff point for predicting incident NALFD was 81 cm in men and 78.5 cm in women, which might assist in the early detection and prevention of NAFLD.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kwon, Yu-Jin(권유진) ORCID logo https://orcid.org/0000-0002-9021-3856
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
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