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Cutoff Points of Waist Circumference for Predicting Incident Non-Alcoholic Fatty Liver Disease in Middle-Aged and Older Korean Adults

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dc.contributor.author권유진-
dc.contributor.author이혜선-
dc.date.accessioned2022-08-23T00:40:35Z-
dc.date.available2022-08-23T00:40:35Z-
dc.date.issued2022-07-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/189560-
dc.description.abstractThis study aimed to determine the optimal cutoff value of waist circumference (WC) for predicting incident NAFLD. In this community-based prospective cohort study, we analyzed data from 5400 participants without NAFLD at baseline aged 40-69 years. NAFLD was defined as a NAFLD-liver fat score >-0.640. A Cox proportional hazards regression model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for an association between body composition and NAFLD incidence. The predictive power of each body composition indicator was assessed by Harrell's concordance index for Cox models. During a mean follow-up period of 12 years, there were 2366 new-onset NAFLD events. Compared with men with WC < 81 cm, the adjusted HR (95% CI) for incident NAFLD in those with WC ≥ 81 cm was 2.44 (2.23-2.67). Compared with women with WC < 78.5 cm, the adjusted HR (95% CI) for incident NAFLD in those with WC ≥ 78.5 cm was 2.54 (2.25-2.87). WC was the most significant risk factor for predicting incident NAFLD among body composition indicators in middle-aged and older Korean adults. The optimal WC cutoff point for predicting incident NALFD was 81 cm in men and 78.5 cm in women, which might assist in the early detection and prevention of NAFLD.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI Publishing-
dc.relation.isPartOfNUTRIENTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBody Mass Index-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNon-alcoholic Fatty Liver Disease* / diagnosis-
dc.subject.MESHNon-alcoholic Fatty Liver Disease* / epidemiology-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHRisk Factors-
dc.subject.MESHWaist Circumference-
dc.titleCutoff Points of Waist Circumference for Predicting Incident Non-Alcoholic Fatty Liver Disease in Middle-Aged and Older Korean Adults-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학교실)-
dc.contributor.googleauthorJun-Hyuk Lee-
dc.contributor.googleauthorSoyoung Jeon-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorYu-Jin Kwon-
dc.identifier.doi10.3390/nu14142994-
dc.contributor.localIdA04882-
dc.contributor.localIdA03312-
dc.relation.journalcodeJ02396-
dc.identifier.eissn2072-6643-
dc.identifier.pmid35889950-
dc.subject.keywordabdominal obesity-
dc.subject.keywordbody mass index-
dc.subject.keywordnon-alcoholic fatty liver disease-
dc.subject.keywordwaist circumference-
dc.contributor.alternativeNameKwon, Yu-Jin-
dc.contributor.affiliatedAuthor권유진-
dc.contributor.affiliatedAuthor이혜선-
dc.citation.volume14-
dc.citation.number14-
dc.citation.startPage2994-
dc.identifier.bibliographicCitationNUTRIENTS, Vol.14(14) : 2994, 2022-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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