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Non-HDL cholesterol as a predictor for incident type 2 diabetes in community-dwelling adults: longitudinal findings over 12 years

 In-Ho Seo  ;  Da-Hye Son  ;  Hye Sun Lee  ;  Yong-Jae Lee 
 TRANSLATIONAL RESEARCH, Vol.243 : 52-59, 2022-05 
Journal Title
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Adult ; Cholesterol ; Cholesterol, HDL ; Cohort Studies ; Diabetes Mellitus, Type 2* / genetics ; Female ; Humans ; Independent Living ; Lipoproteins ; Male ; Proportional Hazards Models ; Risk Factors
Non-HDL cholesterol is a simple measure to analyze the total amount of proatherogenic lipoproteins in the blood and to predict development of cardiovascular disease. However, it is unclear whether non-HDL cholesterol has a relationship with incident type 2 diabetes. This study aimed to evaluate the association between non-HDL cholesterol and incident type 2 diabetes with a large-sample, community-based Korean cohort over a 12-year period. Among the 10,038 total participants, 7608 (3662 men and 3946 women) without diabetes were selected from the Korean Genome and Epidemiology Study (KoGES). Their non-HDL cholesterol level was divided into quartiles. The hazard ratios (HRs) with 95% confidence intervals (CIs) for incident type 2 diabetes were calculated using multivariate Cox proportional hazards regression models after adjusting for potentially confounding variables. In total, 1442 individuals (18.9%: 1442 of 7608) developed type 2 diabetes during the 12-year follow up period, with an incident rate of 3.0-5.0. Compared to the reference first quartile, the HRs (95% CIs) of incident type 2 diabetes for the second, third, and fourth quartiles increased in a dose-response manner after adjusting for potentially confounding variables, including the HOMA-IR marker. Non-HDL cholesterol level at baseline could be a future predictor of type 2 diabetes even when prior glucose or insulin (HOMA-IR) levels are normal.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Seo, Inho(서인호) ORCID logo https://orcid.org/0000-0001-8280-7745
Son, Da‐Hye(손다혜) ORCID logo https://orcid.org/0000-0001-7464-996X
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
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