Cited 1 times in
Non-HDL cholesterol as a predictor for incident type 2 diabetes in community-dwelling adults: longitudinal findings over 12 years
DC Field | Value | Language |
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dc.contributor.author | 서인호 | - |
dc.contributor.author | 손다혜 | - |
dc.contributor.author | 이용제 | - |
dc.contributor.author | 이혜선 | - |
dc.date.accessioned | 2022-05-09T17:00:50Z | - |
dc.date.available | 2022-05-09T17:00:50Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 1931-5244 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188331 | - |
dc.description.abstract | Non-HDL cholesterol is a simple measure to analyze the total amount of proatherogenic lipoproteins in the blood and to predict development of cardiovascular disease. However, it is unclear whether non-HDL cholesterol has a relationship with incident type 2 diabetes. This study aimed to evaluate the association between non-HDL cholesterol and incident type 2 diabetes with a large-sample, community-based Korean cohort over a 12-year period. Among the 10,038 total participants, 7608 (3662 men and 3946 women) without diabetes were selected from the Korean Genome and Epidemiology Study (KoGES). Their non-HDL cholesterol level was divided into quartiles. The hazard ratios (HRs) with 95% confidence intervals (CIs) for incident type 2 diabetes were calculated using multivariate Cox proportional hazards regression models after adjusting for potentially confounding variables. In total, 1442 individuals (18.9%: 1442 of 7608) developed type 2 diabetes during the 12-year follow up period, with an incident rate of 3.0-5.0. Compared to the reference first quartile, the HRs (95% CIs) of incident type 2 diabetes for the second, third, and fourth quartiles increased in a dose-response manner after adjusting for potentially confounding variables, including the HOMA-IR marker. Non-HDL cholesterol level at baseline could be a future predictor of type 2 diabetes even when prior glucose or insulin (HOMA-IR) levels are normal. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | TRANSLATIONAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cholesterol | - |
dc.subject.MESH | Cholesterol, HDL | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Diabetes Mellitus, Type 2* / genetics | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Independent Living | - |
dc.subject.MESH | Lipoproteins | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Non-HDL cholesterol as a predictor for incident type 2 diabetes in community-dwelling adults: longitudinal findings over 12 years | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | In-Ho Seo | - |
dc.contributor.googleauthor | Da-Hye Son | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Yong-Jae Lee | - |
dc.identifier.doi | 10.1016/j.trsl.2021.12.008 | - |
dc.contributor.localId | A05137 | - |
dc.contributor.localId | A05543 | - |
dc.contributor.localId | A02982 | - |
dc.contributor.localId | A03312 | - |
dc.relation.journalcode | J03229 | - |
dc.identifier.eissn | 1878-1810 | - |
dc.identifier.pmid | 34979322 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1931524421003054 | - |
dc.contributor.alternativeName | Seo, Inho | - |
dc.contributor.affiliatedAuthor | 서인호 | - |
dc.contributor.affiliatedAuthor | 손다혜 | - |
dc.contributor.affiliatedAuthor | 이용제 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.citation.volume | 243 | - |
dc.citation.startPage | 52 | - |
dc.citation.endPage | 59 | - |
dc.identifier.bibliographicCitation | TRANSLATIONAL RESEARCH, Vol.243 : 52-59, 2022-05 | - |
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