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Association Between the Severity of Periodontitis and Osteoarthritis in Middle-Aged and Older Patients With Type 2 Diabetes Mellitus: A Nationwide Population-Based Study

 Hyoung-Sik Kim  ;  Hye-Min Park  ;  Haeyoung Kim  ;  Hye Sun Lee  ;  Da-Hye Son  ;  Yong-Jae Lee 
 ARTHRITIS CARE & RESEARCH, Vol.74(3) : 403-409, 2022-03 
Journal Title
Issue Date
Aged ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 / epidemiology* ; Female ; Health Surveys ; Humans ; Male ; Middle Aged ; Osteoarthritis / epidemiology* ; Osteoarthritis / etiology ; Periodontitis / epidemiology* ; Republic of Korea ; Severity of Illness Index
Objective: Periodontitis and osteoarthritis are major public health concerns that result in decreased quality of life among middle-aged and older adults. We sought to examine whether the severity of periodontitis is related to osteoarthritis according to the presence of type 2 diabetes mellitus.

Methods: This study included 3,527 participants age ≥50 years from the Korean National Health and Nutrition Examination Survey. Periodontitis was assessed using the Community Periodontal Index; severe periodontitis was defined as periodontal tissue forming deep periodontal pockets ≥6-mm depth. Osteoarthritis was defined as Kellgren/Lawrence grade ≥2 on radiographic images of the knee or hip area with joint pain. The odds ratios (ORs) and 95% confidence intervals (95% CIs) for osteoarthritis according to the severity of periodontitis, stratified by type 2 diabetes mellitus, were calculated using multiple logistic regression analyses.

Results: Participants with type 2 diabetes mellitus were more likely to have osteoarthritis as the severity of periodontitis increased (nonsevere periodontitis OR 1.23 [95% CI 0.67-2.32]; severe periodontitis OR 3.01 [95% CI 1.51-5.84]) after adjusting for age, sex, body mass index, smoking status, alcohol consumption, regular exercise, education level, household income, hypertension, and frequent tooth-brushing. However, this positive association was not found in individuals without type 2 diabetes mellitus after adjusting for the same covariables.

Conclusion: Severe periodontitis was positively and significantly associated with osteoarthritis in middle-aged and older individuals with type 2 diabetes mellitus. Our findings suggest that the oral inflammation manifesting in periodontitis may be at least partly involved in the pathogenesis of osteoarthritis, particularly in patients with type 2 diabetes mellitus.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Hyoung Sik(김형식) ORCID logo https://orcid.org/0000-0002-9303-4116
Park, Hye-Min(박혜민)
Son, Da‐Hye(손다혜) ORCID logo https://orcid.org/0000-0001-7464-996X
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
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