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Semi-Quantitative Analysis for Determining the Optimal Threshold Value on CT to Measure the Solid Portion of Pulmonary Subsolid Nodules

Other Titles
 폐의 아고형결절에서 침습적 병소를 검출하기 위한 반-정량 분석을 통한 최적의 CT 임계 값 결정 
 Sunyong Lee  ;  Da Hyun Lee  ;  Jae Ho Lee  ;  Sungsoo Lee  ;  Kyunghwa Han  ;  Chul Hwan Park  ;  Tae Hoon Kim 
 Journal of the Korean Society of Radiology(대한영상의학회지), Vol.82(3) : 670-681, 2021-05 
Journal Title
Journal of the Korean Society of Radiology(대한영상의학회지)
Issue Date
Lung Neoplasms ; Solitary Pulmonary Nodule ; Adenocarcinoma of Lung ; Multidetector Computed Tomography
This study aimed to investigate the optimal threshold value in Hounsfield units (HU) on CT to detect the solid components of pulmonary subsolid nodules using pathologic invasive foci as reference.

Materials and Methods
Thin-section non-enhanced chest CT scans of 25 patients with pathologically confirmed minimally invasive adenocarcinoma were retrospectively reviewed. On CT images, the solid portion was defined as the area with higher attenuation than various HU thresholds ranging from −600 to −100 HU in 50-HU intervals. The solid portion was measured as the largest diameter on axial images and as the maximum diameter on multiplanar reconstruction images. A linear mixed model was used to evaluate bias in each threshold by using the pathological size of invasive foci as reference.

At a threshold of −400 HU, the biases were lowest between the largest/maximum diameter of the solid portion of subsolid nodule and the size of invasive foci of the pathological specimen, with 0.388 and −0.0176, respectively. They showed insignificant difference (p = 0.2682, p = 0.963, respectively) at a threshold of −400 HU.

For quantitative analysis, −400 HU may be the optimal threshold to define the solid portion of subsolid nodules as a surrogate marker of invasive foci.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae Hoon(김태훈) ORCID logo https://orcid.org/0000-0003-3598-2529
Park, Chul Hwan(박철환) ORCID logo https://orcid.org/0000-0002-0004-9475
Lee, Sung Soo(이성수) ORCID logo https://orcid.org/0000-0001-8998-9510
Han, Kyung Hwa(한경화)
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